Glycopeptidolipids

Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS)... 

Clusters of arabinofuranosyl units at the nonreducing ends of the chains are esterified with mycolic acids (Section a,l).10 604 605 Mycobacteria also contain lipoarabinomannans that act as major antigens.603 606 Some mycobacterial species synthesize small glycopeptidolipids that may disrupt cell membranes of hosts.607 Mycobacteria don t produce toxins of usual types but cause slow, long-lasting infections. 

Cell walls of mycobacteria are composed of a peptidoglycan with covalently attached galactan chains. Branched chains of arabinan, a polymer of the furanose ring form of arabinose with covalently attached mycolic acids, are glycosidically linked to the galactan.327 Shorter glycopeptidolipids, containing... 

Structures of the Oligosaccharide Haptens from Glycopeptidolipid Antigens from Other Mycobacteria... 

Synthesis and Antigenicity of Neoglycoconjugates Related to the Glycopeptidolipids of the M. avium Complex... 

G. O. Aspinall, N. K. Khare, R. K. Sood, D. Chatterjee, B. Rivoire, and P. J. Brennan, Structure of the glycopeptidolipid antigen of serovar 20 of the Mycobacterium avium serocomplex, synthesis of allyl glycosides of the outer di- and tri-saccharide units of the antigens of serovars 14 and 20, and serology of the derived neoglycoproteins, Carbohydr. Res., 216 (1991) 357-373. 

Z. Varga, I. Bajza, G. Batta, and A. Liptak, Synthesis of the pentasaccharide hapten from the glycopeptidolipid antigen of Mycobacterium avium serovar 17, Tetrahedron Lett., 42 (2001)... 

Both D-and L-rhamnose may be present in the same oligosaccharide, as reported for the glycopeptidolipids of Mycobacterium avium.232 The surface antigens of all serovars examined present the inner disaccharide a-L-rhainnopyranosyl(l—>2)-6-deoxy-a-L-talopyranose. L-Rhamnose is also part of the highly immunogenic phenolic glycolipids from Mycobacterium 33... 

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