Glycolipids receptors

Ma ZF, Li JR, Jiang L, Cao J, Boullanger P. Influence of the spacer length of glycolipid receptors in polydiacetylene vesicles on the colorimetric detection of Escherichia coli. Langmuir 2000 16 7801-7804. 

For similar reasons, that is to investigate the inhibition of adhesion of pathogens to glycolipid receptors in host cells, Magnusson and co-workers [146] have prepared the 3-0-methyl-, 3-deoxy-3-C-methyl and the 3-deoxy derivatives of the P-methyl glycoside of the disaccharide gal-a-(l -> 4)-gql. The P-methyl galactoside (150) was converted into the benzyl ether (151) using benzyl trichloracetimidate [147] and then... 

Stromberg N, Nyholm P-G, Pascher I, Normark S. Saccharide orientation at the cell surface affects glycolipid receptor function. 

Lingwood CA. Aglycone modulation of glycolipid receptor func- 27. tion. Glycoconj. J. 1996 13 495-503. 

Boyd B, Zhiuyan Z, Magnusson G, Lingwood CA. Lipid modulation of glycolipid receptor function Presentation of galactose 1 galactose disaccharide for Verotoxin binding in natural and synthetic glycolipids. Eur. J. Biochem. 1994 223 873-878. 188. 

Mylvaganam M, Lingwood C. Adamantyl globotriaosyl ceramide—a monovalent soluble glycolipid mimic which inhibits verotoxin binding to its glycolipid receptor. Biochem. Biophys. 209. Res. Commun. 1999 257 391-394. 

The role of glycolipids is still unclear. Certain glycolipid molecules may bind bacterial toxins, as well as bacterial cells, to animal cell membranes. For example, the toxins that cause cholera, tetanus, and botulism bind to glycolipid cell membrane receptors. Bacteria that have been shown to bind to glycolipid receptors include E. coli, Streptococcus pneumoniae, and Neisseria gonorrhoeae, the causative agents of urinary tract infections, pneumonia, and gonorrhea, respectively. 

Khan AS, Johnston NC, Goldfine H et al. (1996) Porcine 987P glycolipid receptors on intestinal brush borders and their cognate bacterial ligands. Infect Immun 64 3688-3693... 

Sung MA, Fleming K, Chen HA et al. (2001) The solution structure of PapGII from uropathogenic Escherichia coli and its recognition of glycolipid receptors. EMBO Rep 2 621-627... 

Glycolipids can be incorporated in liposomes, directly captured on the matrix of the sensor chip (Figure 4), and completely removed after a measurement [22], In a similar approach using immobilized antibodies for liposome capture, bacterial toxin affinity and binding specificity for glycolipid receptors were determined [8]. 

MacKenzie C. R., Hirama T., Deng S., Bundle D. R., Narang S. A. and Young N. M. (1997) Quantitative analysis of bacterial toxin affinity and specificity for glycolipid receptors by surface plasmon resonance, J. Biol. Chem. 272 5533-5538. 

Several examples of the induction of apoptosis in host cells following attachment of bacteria which recognize glycolipid receptors have been reported [71, 72]. Addition of bacterial sphingomyelinase is a procedure commonly used in cell biology to increase eukaryotic cell ceramide levels in signaling studies [73]. 

Lingwood, C. A., Aglycone Modulation of Glycolipid Receptor Function, Glycoconj J, 1996, 73 495-503. 

Stromberg, N., Nyholm, P.-G., Pascher, I. and Normark, S., Saccharide orientation at the cell surface affects glycolipid receptor function, Proc Natl Acad Sci USA, 1991, 33 9340-9344. 

Saitoh, T., Natomi, H., Zhao, W, Okuzumi, K., Sugano, K., Iwamori, M. and Nagai, Y., Identification of glycolipid receptors for Helicobacter pylori by TLC-immunostaining, FEBS... 

Hartmann, E. and Lingwood, C. A., Brief heat shock induces a long-lasting alteration in the glycolipid receptor binding specificity of Hemophilus influenzae.. Infect Immun, 1997, 63 1729-1733. 

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