Glycogen Glucose-6-phosphatase

Rat Time (hours) Per cent G-6-P to glycogen Glucose-6-phosphatase... 

The enzyme pattern of the placenta varies with the stage of development. For example, although early in development the placenta (in contrast to the fetal liver) has high glucose-6-phosphatase activity and glycogen content, placental glycogen and glucose-phosphatase activities are low at term. 

Gilboe, D. P., and Nuttall, F. Q., 1978, In vivo glucose-, and glucagon-, and cAMP-induced changes in liver glycogen synthase phosphatase activity, J. Biol. Chem. 253 4078. 

Type 1 Von Gierke s disease Deficiency of glucose-6-phosphatase Liver cells and renal tubule cells loaded with glycogen. Hypoglycemia, lactic-acidemia, ketosis, hyperlipemia. 

Di-tt-octylphthalate has been shown to be a mild liver toxin at high doses in acute- and intermediate-duration studies in rodents. While the mechanism of action for these hepatic effects is not known, di-w-octylphthalate does not appear to behave like other phthalate esters such as di(2-ethylhexyl)phthalate, which have been shown to be hypolipidemic peroxisome proliferators. Instead, the liver changes associated with exposure to di- -octylphthalate are characterized by marked centrilobular accumulation of fat and loss of glycogen, accompanied by reduced glucose-6-phosphatase activity and some centrilobular necrosis. 

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