Glycochenodeoxycholate

Sodium glycochenodeoxycholate [16564-43-5] M 472.6, Dissolved in EtOH, filtered and concentrated to crystallisation, and recrystallised from a little EtOH. 

Figure 4.14 Structures of cholic and chenodeoxycholic acids which are the acids that form the bile salt The asterisk indicates the position at which an ester bond is formed with taurine or glycine so that bile salts are taurocholate, chenodeoxytaurocholate, gly-cocholate, and glycochenodeoxycholate are formed. The structure of taurine is H2NCH2CH2SO3 and glycine is H2NCH2COOH.

Abbreviations used for bile acids in Tables 3.1-3.6 DOC (deoxycholate), LC (lithocholate), CDOC (chenodeoxycholate), C (cholate), GDOC (glycodeoxycholate), TDOC (taurodeoxy-cholate), GCDOC (glycochenodeoxycholate), TCDOC (taurochenodeoxycholate), GC (gly-cocholate), TC (taurocholate). 

D. Komichi, S. Tazuma, T. Nishioka, H. Hyogo and K. Chayama, Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage, Free Radio. Biol. Med., 2005, 39(11), 1418. 

H. Higuchi, S. F. Bronk, Y. Takikawa, N. Werneburg, R. Takimoto, W. El-Deiry and G. J. Gores, The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis, J. Biol. Chem., 2001, 276(42), 38610. 

Fig. 3 Electrophoretic ionic mobilities fj, of propranolol as influenced by BS concentration buffer x mM BS, 20 mM phosphate, pH = 7.4, detection 220 nm m— electrophoretic ionic mobility /r, GC—glycocholic acid, GDC—glycodeoxycholic acid, GCDC—glycochenodeoxycholic acid.

During a Dissolution of Cholesterol Monohydrate in Glycochenodeoxycholate-Glycoursodeoxycholate-Lecithin Solutions and Calcium Carbonate Solubility in Their Solutions... 

Solubility of calcium carbonate was measured in mixed solutions of glycochenodeoxycholate, glyooursodeoxycholate and lecithin in the presence of cholesterol monohydrate disk in the ranges of pH from 7.5 to 9.0. ... 

Glycochenodeoxycholate cuid glycoursodeoxycholate are known to reduce the cholesterol saturation in bile and to irxiuce the dissolution of cholesterol gallstones in humans.1/2,3)... 

Table 5.4.6 Serum BA composition in healthy subjects (1,2), in a patient (3) with primary biliary cirrhosis (PBC) before (A) and after (B) treatment with ampicillin and in a patient (4) with PBC before (A) and after (B) treatment with UDCA. Results are expressed in nmol/ml. RDS% of three measurements was in the range 3.1-7.5%. - Means -detectable value (adapted from [20]). GCA glycocholic acid, GDCA glycodeoxycholic acid, GCDCA glycochenodeoxycholic acid, GLCA glycolithocholic acid,...

Sodium glycocholate Sodium glycochenodeoxycholate A Sodium glycodeoxycholate... 

Sodium glycochenodeoxycholate [16564-43-5] M 472.6, m 245-250°, [a] -h41.2° (c 1, H2O). Dissolve it in EtOH, filter it and concentrate it to crystallisation, and recrystallise from a little EtOH. It also recrystallises from EtOH/Et20. [Beilstein 10 IV 1611.]... 

A cytosolic sulfotransferase has been identified in rat liver and kidney which utilizes 3 -phosphoadenosine-5 -phosphosulfate (PAPS) and shows a greater rate of sulfation for glycolithocholate than lithocholate. In an assay with the enzyme preparation, PAPS, and conjugated bile acids, 3 unidentified products were formed from taurocholate suggesting multiple sulfation of more polar conjugated bile acids [64]. The enzyme from liver, proximal intestine or adrenals of hamster produced only glycochenodeoxycholate 7-sulfate. Comparable results with the enzyme from kidney will be discussed in Section VI.3. Hepatic enzyme from the female hamster shows 4-fold greater activity than that of the male [65]. 

ND, not determined GC, glycocholic acid TC, taurocholic acid GCDC, glycochenodeoxycholic acid ... 

ND. not determined CDC, chenodeoxycholic acid GCDC, glycochenodeoxycholic acid UDC, ursodeoxycholic acid GUDC, glycoursodeoxycholic acid. 

---