Cytosolic sulfotransferases

Hempel N, Barnett A, Gamage N, Duggleby RG, Windmill KF, Martin JM, McManus ME (2005) Human SULT1A SULTs. In Pacifici GM and Coughtrie MW (eds.) Human Cytosolic Sulfotransferases. CRC Press, Boca Raton, FL, pp. 43-61. 

Falany JL et al (2006) Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases. Drug Metab Dispos 34 361-368... 

Nowell S et al (2006) Pharmacogenetics of human cytosolic sulfotransferases. Oncogene 25 1673-1678... 

Falany, J.L. and Falany, C.N. (2007) Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene. The Journal of Steroid Biochemistry and Molecular Biology, 107, 202-210. 

Pacifid, G.M. (2005) Sulfation of drugs, in Human Cytosolic Sulfotransferases (eds... 

Banoglu, E. Current status of the cytosolic sulfotransferases in the metaboUc activation of promutagens and procarcinogens. Curr. Drug Metab. 2000,1,1-30. 

A cytosolic sulfotransferase has been identified in rat liver and kidney which utilizes 3 -phosphoadenosine-5 -phosphosulfate (PAPS) and shows a greater rate of sulfation for glycolithocholate than lithocholate. In an assay with the enzyme preparation, PAPS, and conjugated bile acids, 3 unidentified products were formed from taurocholate suggesting multiple sulfation of more polar conjugated bile acids [64]. The enzyme from liver, proximal intestine or adrenals of hamster produced only glycochenodeoxycholate 7-sulfate. Comparable results with the enzyme from kidney will be discussed in Section VI.3. Hepatic enzyme from the female hamster shows 4-fold greater activity than that of the male [65]. 

Part II Sulfate Conjugate-Dependent Toxicity Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation... 

Falani CN. Enzymology of human cytosolic sulfotransferases. FASEB J. 1997 11 206-216. 

Blanchard et al., 2004 Blanchard RL, Freimuth RR. et al. A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics 2004 14(3) 199-211. 

Anderson RJ, Kudlacek PE, Clemens DL. Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact 1998 109 53-67. 

Pai TG, Suiko M, Sakakibara Y, Liu MC. Sulfation of flavonoids and other phenolic dietary compounds by the human cytosolic sulfotransferases. Biochem Biophys Res Commun 2001 285 1175-1179. 

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