N-Phenyl glycine

AI3-15398 EINECS 243-133-1 Glycine, N-phenyl-, monopotassium salt N-Phenylglycine potassium salt NSC 405072 Potassium N-phenylglycinate. 

CAS 103-01-5 EINECS/ELINCS 203-070-2 Synonyms Anilinoacetic acid Glycine, N-phenyl- (Phenylamino) acetic acid Empirical C8H9NO2 Formula C6H5NHCH2COOH Properties Yel. to tan cryst. powd. sol. in water, alcohols, toluene, acetone sparingly sol. in ether m.w. 151.17 m.p. 121-123 C Toxicology May be harmful by ing., inh., skin absorp. may cause eye/skin irritation TSCA listed... 

Acetic anhydride, condensation with and acetylation of glycine, 46, 1 in cyclization of c-formylphenoxy-acetic acid to coumarone, 46, 28 in cyclization of hippuric acid to 2-phenyl-5-oxazolone, 47, 101 reaction with N-nitroso-N-phenyl-glycine to yield 3-phenylsydnone, 46,96... 

Tertiary amines were amongst the first initiators of NCA polymerisation which had been described in the literature and it seems that the polymerisation of all the known NCA s may be accomplished by their action. Wessely (77) reported in 1925 that glycine and phenyl alanine NCA s are readily polymerised in pyridine at ambient temperatures, and in the following paper (72) he reported a similar polymerisation of sarcosine NCA. The polypeptides produced by this initiator apparently formed cyclic polymers since no terminal end groups could be detected 41). It is significant that appreciable quantities (a few %) ot 3-acetic-hydantoin derivatives were found in the polymers formed from glycine and phenyl alanine NCA s but none was detected in the polymerised sarcosine NCA (72). This evidence suggests that the mechanisms of polymerisation initiated by aprotic bases may be different for the non-N-substituted NCA and the N-substituded anhydrides. 

Butyrate (CAB) Binder, Sensitized with Methylene Blue (MB), and Containing as Activators Either N-Phenyl-glycine (NPG) or Tri(r -butyl)-benzylstannane (TBBS)a... 

Flash photolysis and laser flash photolysis are probably the most versatile of the methods in the above list they have been particularly useful in identifying very short-lived intermediates such as radicals, radical cations and anions, triplet states, carbenium ions and carbanions. They provide a wealth of structural, kinetic and thermodynamic information, and a simplified generic experimental arrangement of a system suitable for studying very fast and ultrafast processes is shown in Fig. 3.8. Examples of applications include the keton-isation of acetophenone enol in aqueous buffer solutions [35], kinetic and thermodynamic characterisation of the aminium radical cation and aminyl radical derived from N-phenyl-glycine [36] and phenylureas [37], and the first direct observation of a radical cation derived from an enol ether [38],... 

Glycin a-Chlor-N-(phenyl-acetyl)- -ethylester E14a/3, 292 (OH Ci)... 

Glycin N-Benzoyl-2-(2-thienyl)-El6d, 523 (—OH - -Ar) Oxaziridin 2-Benzolsulfonyl-3-phenyl- E13/2, 1363/E14a, 546 (C,N-Epoxygenierung)... 

This substance has also been prepared by the action of cold concentrated ammonium hydroxide on N-(phenyl-p-arsinic acid)-glycine methyl ester, an 80 per cent, yield being obtained. 

N-(Phenyl-p-arsinic acid)-glycine ethyl ester forms delicate needles from 50 per cent, alcohol, melting with decomposition at about 270° C. 

N-(Phenyl-p-ar8inic acid)-glycine-ethylamide occurs in crusts of platelets, darkening above 250° C., and decomposing at 278° to 280° C. It is soluble in warm alcohol. 

N-(Phenyl - p - arsinic acid)- glycine - 4 - acetylaminobenzyl-amide,AsO(OH)a.C8H4.NH.CHa.CO.NH.CH2.C8H4.NH.CO.CHs, occurs in flat, microscopic needles, which remain unmelted at 280° C. From 50 per cent, alcohol it deposits diamond-shaped plates. It forms a sodium salt, crystallising in microscopic needles, containing 4j molecules of water of crystallisation. 

N-(Phenyl-p-arsinic acid)-glycine-4 -carbamidobenzylamide, AsO(OH)2.C8H4.NH.CHa.CO.NH.CH2.C6H4.NH.CO.NHij, has only been obtained in very poor yield. 

N -(Phenyl -p -arsinic acid) - glycine-3 -methyl -4 -acetylamino -benzylamide, AsO(OH)2.CeH4.NH.CH2.CO.NH.CHa.C6H3(CH3)(NH. CO.CH3), is deposited in flat minute needles from 50 per cent, sdcohol. When rapidly heated it decomposes at 278° C. The sodium salt yields mioroscopie needles from 85 per cent, alcohol. 

N-(Phenyl-p-arsinic acid) - glycine - a - aminopropionamide, AsO(OH)2.C 4.NH.CH(CHs).CO.NHa, is obtained by employing a-bromopropionamide in the condensation. From water or hot 50 per cent, alcohol, thin hexagonal plates are deposited, darkening at 255° C. and decomposing at 262° to 263-6° C. The sodium salt forms flat, microscopic needles, containing about 2 - molecules of water. 

N-(Phenyl-l-amino-4-arsinic acid)-glycine-amide, (HO)20As. C8Hj(NHg).NH.CH2.CO.NH2, is obtained when 3 4-diaminophenyl-arsinie acid in alkaline solution is treated with chloracetamide. It begins to darken at 215° C. and melts with decomposition at 234° to 241° C. If about 25 per cent, more alkali is used in the preparation, 3-amino-6-arsino-l 2-dihydroquinoxaline results ... 

In subsequent process generations, peniciUin G acylase derived enzymes were also used to couple the synthetic side chains, such as D-phenylglycine (ampicillin, cephalexin) and D-p-hydroxyphenylglycine (amoxicillin, cephadroxil) in the form of amino acid amides or esters to 6-APA and 7-ADCA (Scheme 4.6D). Biotransformation routes to the n-phenylglycine and n-p-hydroxyphenylglycine side chains were also developed (Scheme 4.6C), but the enzymatic process towards n-phenyl-glycine amide has been substituted by a classical resolution. 

Inductor N-carbamoyl- D-phenylglycine urea, N-carbamoyl-phenyl-glycine, N-carbamoyl-phe-nylglycine (for the wild strain) strain was genetically engineered - no data are given on this N-carbamoyl-P-alanine N-ca rb amoy 1- P-alanine... 

Aromatic compounds, carboxylation of, 28 L-Asparagine, carbobenzoxy- [L-Asparagine, -[(phenylmethoxy[carbonyl]-], 89 L-Asparagine, IP -(trifluoroacetyl)-, 125 L-ASPARAGINYL-L-LEUCINE, CARBOBENZOXY-, METHYL ESTER [L-LEUCINE, A -[AT -[(PHENYLMETH-OXY)CARBONYL] -L-ASPAR-GINYL] -, METHYL ESTER, 88 2-Asp.Gly-OEt [Glycine, N- [Al -[(phenyl-methoxy)carbonyl] -L-asparaginyl] -, ethyl ester], 93... 

Owing to the substitution of the hydrogen atom by phenyl in the position represented in carbethoxyl-glycyl-N-phenyl-glycine ester, no transformation into the lactim form can take place. On hydrolysis it yielded the dipeptide glycyl-phenylglycine, with loss of carbonic acid,... 

Carbethoxyl-N-phenyl-glycyl-glycine ester on hydrolysis yielded the add... 

Aniline violet. See Basic violet 3 Aniline yellow. See p-Phenylazoaniline Anilinium chloride. See Aniline hydrochloride Anilinoacetic acid. See N-Phenyl glycine p-Anilinoaniline. See N-Phenyl-p-phenylenediamine... 

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