Glycine epilepsies

Of the various amino acid neurotransmitters which have been implicated in epilepsy, the inhibitory transmitter glycine has been shown to be present in normal concentrations, or even slightly elevated, in the vicinity of the... 

Keywords Ionotropic receptors Co-agonism NMDA antagonists Glycine antagonists Stroke Pain Metabotropic receptors Epilepsy... 

Generalized epilepsy with febrile convulsions (GEES) SCNl B (P1 subunit) Cysteine to glycine Slowed inactivation of sodium channel a-subunits... 

A very rare inborn error of metabolism in which high levels of glycine are found in blood and urine. It is probably due to a deficiency of the enzyme, glycine decarboxylase. Affected individuals suffer from gross mental disturbances and in many cases have epilepsy. 

Synonymously called the solute carrier 6 family (SLC-6), NSS members include the sodium-and chloride-dependent transporters for GABA, dopamine, serotonin, norepanephrine and glycine, but also just sodium-dependent transporters of amino acids. Thus, the protein family is of particular medical importance, as many CNS diseases like depression, anxiety or epilepsy can be targeted by inhibiting transporters (Iversen, 1971). 

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