Glyceryl ether phospholipid

Compare the structures and biosynthetic pathways of the glyceryl ether phospholipids, including platelet-activating factor and plasmalogens, with those of the glyceryl ester... 

Infrared spectra have been used as part of an investigation (Hanahan et al., 1963) to prove that a glyceryl ether phospholipid (XL),... 

Thompson, G. A., and D. J. Hanahan Identification of a-glyceryl ether phospholipids as major lipid constituents in two species of terrestrial slug. J. biol. Chem. 238, 2628—31 (1963a). 

A ubiquitous phospholipid mediator (acetyl-glyceryl-ether-phosphorylcholine) in inflammation. Among others, it stimulates platelet aggregation and causes swelling, smooth contraction or dilation and neutrophil activation. 

A few cyclic phospholipid analogues 35a-c (n=13,15,17) were prepared in 78, 38, and 85% yields respectively, by reacting the corresponding 1-glyceryl ethers... 

Figure D1.6.6 latroscan TLC-FID chromatograms of (A) a lipid fraction enriched with neutral lipids isolated from cod flesh and stored in ice (B) neutral lipids spiked with authentic 1 -0-palmityl-glyceryl ether dipalmitate (GE), coinciding in position with authentic highly unsaturated acids such as 22 6n-3 (C) hydrogenated neutral lipids spiked with GE. The solvent system was 97 3 1 (v/v/v) hexane/diethyl ether/formic acid for 40 min. Abbreviations O, origin SF, solvent front FFA, free fatty acid PL, phospholipids SE, steryl ester ST, free sterol TG, triglyceride. Reproduced from Ohshima et al. (1987) with permission from AOCS Press.

Hanahan, D. J., Ekholm and Jackson, C. M. (1963) Studies on the structure of the glyceryl ether and the glycerylether phospholipids of bovine erythrocytes, Biochemistry 2, 630-641. 

Butyl octyl benzoate Dicocodimethylamine dimerate Distearyidimethylamine dilinoleate Hexyldecyl benzoate Jsopropyl stearate Linoleamidopropyl dimethylamine Linoleamidopropyl dimethylamine dimer dilinoleate Macadamia ternifolia nut oil Oleyl oleate PEG/PPG-8/3 diisostearate Polyquaternium-7 Polyquaternium-22 Polysiloxy linoleyl pyrrolidone phospholipid PPG-27 glyceryl ether Sodium/TEA-lauroyl hydrolyzed keratin... 

Cholesterol is the major (95-99%) sterol in fish oils (Feeley etal, 1972 Kritchevsky etal, 1967). Minor levels of plant sterols have been identified in mackerel, rainbow trout, smelt, sardine and chimera (Takagi et al, 1979). Other fish lipids which have been characterized include wax esters (Nevenzel 1970 Sargent, 1976b), glyceryl ethers (Myher, 1978), plasmalogens, (Kauer et al, 1978), phospholipids... 

TLC is ideally suited for analysing the products of radiochemical syntheses and isolation of labelled compounds from complex reaction mixtures. The method has proved its value, for example, in the preparation of H- or C-tagged fatty acids [628], cholesterol esters [416], glyceryl ethers [425], phospholipids [569] and steroids [328]. 

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