Fish lipid

Leukotriene B5 can be biosynthesized in the body from eicosapentaenoic acid, which is ingested in the form of dietary fish lipid. Synthetic LTB5 was synthesized as outlined below and found to have only 20% of the neutrophil chemotactic activity of LTB4, a fact which may be relevant to the antiinflammatory effect of dietary marine lipid. 

There is a close correlation between the docosohexaenoic acid content of fish lipids and the iodine number. Shulman and Yuneva (1990a, b) showed that the relationship in humpback salmon is Y=-25.69 + 0.185X, where Y is the C22 6o)3 content and X the iodine number of the lipids. Again, iodine numbers can readily be obtained at sea, eliminating the need for gas-liquid... 

Ackman, R.G. (1980). Fish lipids, Part 1. In Advances in Fish Science and Technology (J.J. Connell, ed.), pp. 86-103. Fishing News Books, Oxford. 

Brenner, R.R., Vazza, D.V. and De Tomas, M.E. (1963). Effect of a fat-free diet and of different dietary fatty acids (palmitate, oleate and linoleate) on the fatty composition of freshwater fish lipids. Journal of Lipid Research 4,341-345. 

Lapin, V.I. and Shatunovsky, M.I. (1981). The composition, physiological and ecological significance of fish lipids (In Russian). Uspekhi Sovremennoy Biologii 92,380-393. 

Ota, T. and Yamada, M. (1975). Fatty acids of four fresh-water fish lipids. Bulletin of the Faculty of Fisheries, Hokkaido University 26,277-288. 

Sidorov, V.S. (1983). Ecological Biochemistry of Fish Lipids . Nauka, Leningrad, 240 pp. 

American flagfish, whole fish, fish lipid, Smith etal. 1990)... 

Substances that undergo bioconcentration are hydrophobic and lipophilic, and therefore tend to undergo transfer from water media to fish lipid tissue. The simplest model of bioconcentration views the phenomenon on the basis of the physical properties of the contaminant and does not account for physiologic variables (such as variable blood flow) or metabolism of the substance. Such a simple model forms the basis of the hydrophobicity model of bioconcentration, in which bioconcentration is regarded from the viewpoint of a dynamic equilibrium between the substance dissolved in aqueous solution and the same substance dissolved in lipid tissue. 

Evidence for the validity of the hydrophobicity model of bioconcentration is provided by correlations of it with the octanol-water partition coefficient, Km, using n-octanol as a surrogate for fish lipid tissue. The measurement of Kow consists of determining the concentration of a hydrophobic contaminant in water-immiscible n-oclanol relative to water with which it is in equilibrium. Typical Kow values range from 10 to 107, corresponding to BCF values of 1 to 106. Such Kow/BCF correlations have proven to be reasonably accurate when narrowly defined for a specified class of compounds, most commonly poorly metabolized organohalides. Major inconsistencies appear when attempts are made to extrapolate from one class of contaminants to another. 

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