Glycans, imaging

Fig. 5 Metabolic incorporation of alkyne-tagged sugars in conjunction with CuAAC reaction for glycan imaging and glycoproteomic profiling [87, 90]. CuAAC copper(l)-catalyzed azide-alkyne cycloaddition...

Stockmann H, Neves AA, Stairs S et al (2011) Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells. Chem Sci 2 932-936... 

Sawa M, Hsu TL, Itoh T et al (2006) Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Proc Natl Acad Sci USA 103 12371-12376... 

Chang PV, Prescher JA, Hangauer MJ, Bertozzi CR (2007) Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc 129 8400-8401... 

The conformations we have obtained are illustrated in Figs. 34 and 35, which clearly bring out the disposition in space of the N-acetyl-lac-tosamine isoglycans, and the image obtained conforms entirely with the concept that the glycans are recognition signals. In addition, the essential observations that can be extracted by examination of molecu-... 

As mentioned above. X-ray diffraction of transferrin furnishes little information on the 3D-structure of the glycans and the images we have today remain largely speculative since they result from molecular modelling studies. We have represented in Fig. 21 the 3D-structure, determined by molecular modelling on the basis of X-ray diffraction data of rabbit serotransferrin [276] and of human lactotransferrin [89,92]. In rabbit serotransferrin, the single glycan linked to the peptide chain is immobilized into only... 

Figure 1. Schematic representation of G3-PE013k4accase complex - the ey regions are the glycan residues that serve to anchor the dendritic blocks Protein image obtained from AstexViewer MSD-EBI Database (8)...

S.T. Laughlin, J.M. Baskin, S.L. Amacher, C.R. Bertozzi, In vivo imaging of membrane-associated glycans in developing Zebrafish,... 

Bio-orthogonal chemistry, pioneered by Bertozzi and co-workers, has emerged as a versatile method to image biomolecules such as glycans, lipid-modified proteins, nucleic acids, and secondary metabolites in their... 

Tanaka K, Siwu ERO, Minami K et al (2010) Noninvasive imaging of dendrimer-type N-glycan clusters in vivo dynamics dependence on oligosaccharide structure. Angew Chem hit Ed 49 8195-8200... 

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