Glycan cores

Fig. 15.3. Structures of the four most commonly observed O-glycan cores.

Novel Fucosylated A/-glycan Core Structures in Haemonchus contortus... 

Scheme 4 Structure of the native GPI anchor of human erythrocyte acetylcholineesterase, divided into three main parts the phosphoethanolamine linker (red), the glycan core (black), and the phospholipid tail (green).

Scheme 13 Different Strategies for the Synthesis of Mucin Glycan Core Structures CO2PG1...

Another way that P(l,2)-linked xylose can be removed from plant proteins involves the use of P(l,2)-xylosidase. This is a degradative enzyme that is easily prepared from potatoes. If the 3-position of this maimose is not occupied, P(l,2)-xylosidase releases xylose residues that are P(l,2)-linked to the heta-mannose of an A-glycan core. This techiuque can also be applied to plant-derived therapeutic glycoproteins to remove potential immunogenic epitopes (Lerouge et al., 1998). 

Fig. 2. iV-glycans of the hybrid type. A triantennary structure with sialylated Af-acetyllactosamine (LacNAc) building blocks B biantennary structure with sialylated or fucosylated poly-LacNAc building blocks. The N-glycan core structure is written in bold letters... 

O-glycan core structures in many cells. The core 1 structure is also called T antigen in pathologic studies. Core 1 fSl,3-galactosyltransferases (core 1 fil,3GalT), which are responsible for the synthesis of core 1 disaccharide, have been purified recently (83, 84). 

D-galactosamine 3-P-D-galactosyltransferase activity synthesizing 0-glycan core 1 is controlled by the amino acid sequence... 

Kuhns W, Rutz V, Paulsen H, Malta KL, Baker MA, Burner M, Granovsky M, Brockhausen 1. Processing O-glycan core 1, Gaipi-3GalNAca-R. Specificities of core 2, UDP-GlcNAc ... 

Kuhns W, Jain RK, Malta KL, Paulsen H, Baker MA, Geyer R, Brockhausen 1. Characterization of a novel mucin sulphotrans-ferase activity synthesizing sulphated 0-glycan core 1,3-sulphate- 48. Gaipi-3GalNAca-R. Glycobiology 1995 5(7) 689-697. 

Watt GM, Boons GJ. A convergent strategy for the preparation 43. of N-glycan core di-, tri-, and pentasaccharide thioaldoses for the site-specific glycosylation of peptides and proteins bearing free 44. cysteines. Carbohydr Res. 2004 339 181-193. 

Martin-Lomas s solid-phase synthesis of the glycan core of GPI anchors... 

Core structures of 0-glycans. Core 1 is aiso caiied T antigen... 

Elaboration with 0-glycan core structures, tacKAc repeats, and... 

The complete structure for the GIPLs11,18 showed the glycan core of GPI anchors of proteins,19 xMan-fl - 2)-aMan-(1 6)-aMan-(l >4)-aGlcN-(l - 6)-D-myc>-inositol-... 

M. L. Guther, M. L. de Almeida, N. Yoshida, and M. A. J. Ferguson, Structural studies on the glycosylphosphatidylinositol membrane anchor of Trypanosoma cruzi lG7-antigen. The structure of the glycan core,./. Biol. Chem., 267 (1992) 6820-6828. 

Synthesis of O-glycan cores (a) core 1 3-Gal-T (b) core 3 /33-GlcNAc-T (c) core 2 86-GlcNAc-T (d) core 4 j66-GlcNAc-T ... 

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