Glutathione transferase activity

Wadleigh RW, Yu SJ (1987) Glutathione transferase activity of fall armyworm larvae toward alpha-, beta-unsaturated carbonyl allelochemicals and its induction by allelochemicals. Insect Biochem 17 759-764... 

Wallin H, Morgenstem R. 1990. Activation of microsomal glutathione transferase activity by reactive intermediates formed during the metabolism of phenol. Chem-Biol Interact 75 185-199. 

Gamier, R., Rambourg-Schepens, M.O., Muller, A. Hallier, E. (1996) Glutathione transferase activity and formation of macromolecular adducts in two cases of acute methyl bromide poisoning. Occup. environ. Med., 53, 211-215... 

Taylor, J.B., Vidal, A., Torpier, G., Meyer, D.J., Roitsch, C., Balloul, J.M., Southan, C., Sondermeyer, P., Pemble, S., Lecocq, J.P., Capron, A. and Ketterer, B. (1 988) The glutathione transferase activity and tissue distribution of a cloned mr28k protective antigen of Schistosoma mansoni. EMBO journal 7, 465-472. 

J. Seidegard, R.W. Pero, The Hereditary Transmission of High Glutathione Transferase Activity towards trans-Stilbene Oxide in Human Mononuclear Leukocytes , Human Genet., 69, 66-68 (1985). 

Figure 9.2 Developmental pattern of serum glutathione -transferase activity in female rats. (Adapted from H. Mukhtar and J. R. Bend, Life Sci. 21 1277, 1977.)...

Warholm, M., A.K. Alexandrie, J. Hogberg, K. Sigvardsson, A. Rannug. 1994. Polymorphic distribution or glutathione transferase activity with methyl chloride in human blood. Pharmacogenetics 4(6) 307-311. 

A case-control study has suggested that there is also an increased risk of antituberculosis drug-induced hepatotoxicity in individuals with a glutathione-5-transferase Ml null mutation (23). Reduced glutathione transferase activity could theoretically predispose individuals to adverse effects of toxic metabohtes and xenobiotics. These observations need to be confirmed. 

Glutathione conjugation. The involvement of glutathione transferases in OP metabolism was realized in the early 1960 s (35. 361. It was difficult to establish this fact because of similarities between glutathione transferase-and carboxylesterase-produced metabolites. Induction of glutathione transferase activity in the fall armyworm caused a 2- to 3-fold decrease in the toxicity of diazi-non, methamidophos, and methyl parathion (37.) This shows indirectly the importance of glutathione transferase activity in the detoxification of these OPs. 

There are, as seems to be the rule with enzymes involved in the metabolism of xenobiotics, multiple isoenzymes with glutathione transferase activity. This fact combined with their low substrate specificity is considered to account for the variety of OP metabolites produced as shown in Figure 5 (39). There are at least three different isoenzymes in the house fly (40). One of the house fly glutathione transferases is identical to the enzyme responsible for DDT dehydrochlorination (41). This form is rather substrate specific, and is not known to confer metabolic cross resistance between DDT and any OP. 

Glutathione transferase activities toward herbicides used selectively in soybean. Pest. Sci., 51, 213-222. 

D6. Di llio, C., Del Boccio, G., Aceto, A., Casaccia, R., Mucilli, F., and Federici, G., Elevation of glutathione transferase activity in human lung tumor. Carcinogenesis (London) 9, 335-340 (1988). 

FIO. Fine, G. L., Goldstein, E. J., and Arias, I. M., Localization of glutathione transferase activity in the rabbit nephron using isolated segments. Adaptation in chronic renal failure. Kidney Int. 8, 474 79 (1975). 

Seidegard, J., De-Pierre, J. W., Birberg, W., Pilotti, A., and Pero, R. W., Characterization of soluble glutathione transferase activity in resting mononuclear leukocytes from human blood. Biochem. Pharmacol. 33, 3053-3058 (1984). 

Seidegard, J., Vorachek, W. R., Pero, R. W., and Pearson, W. R., Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci. U.S.A. 85, 7293-7297 (1988). 

Dierickx, P. J., Almar, M. M. and De Jonckheere, J. F. (1990) Glutathione transferase activity in some flagellates and amoebae, and purification of the soluble glutathione transferases from Acanthamoeba. Biochem. Int. 22 593-600. 

Taylor, J. B., Vidal, A., Torpier, G. et al. (1988) The glutathione transferase activity and tissue distribution of a cloned M,28K protective antigen of Schistosoma mansoni. EMBOJ. 7 465-472. 

Chloro-2,4-dinitrobenzene (CDNB) is a substrate often used to monitor glutathione transferase activity because it is easy to measure. 

Kravchenko LV, Avreneva LI, Tutelian VA. Lowering the content of SH-glutathione and glutathione transferase activity in the liver as a factor in increasing the toxicity of T-2 toxin. VoprMed Khim. 1983 29(5) 135-137. Translated from Russian. 

Table 2.16. Glutathione transferase activity and the content of sulfhydryl compounds in...

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