Glutamic acid decarboxylase and

SNA does not affect the concentrations of histamine and glutamic add, but It decreases the activity of glutamic acid decarboxylase and reduces the concentrations of gamma-aminobutyric acid (GABA) In rat brain. 5 GABA release Is Inhibited by acute administration, but not by chronic treatment. 5 SNA Increases serum creatinine phosphoklnase content In stressed rats. Recently, SNA was found to decrease methionine-enkephalin content In the medulla oblongata and mldbraln In the mouse, whereas other areas remained unaffected.48... 

Jennes L, Stumpf W, Bissette G, Nemeroff CB (1984) Monosodium glutamate lesions in rat hypothalamus studied by immunohistochemistry for gonadotropin releasing hormone, neurotensin, tyrosine hydroxylase, and glutamic acid decarboxylase and by autoradiography for [3H] estradiol. Brain Res 308 245-253. 

Benagiano, V., Lorusso, L., Coluccia, A., Tarullo, A., Flace, P., Girolamo, F., Bosco, L., Gagiano, R., Amhrosi, G. (2005). Glutamic acid decarboxylase and GABS immunoreactivities in the cerebellar cortex of adult rat after prenatal exposure to a low concentration of carbon monoxide. Neuroscience 135 897-905. 

Cassel, G., Karlsson, L., Sellstrom, A. (1991). On the inhibition of glutamic acid decarboxylase and gamma-aminobutyric acid transaminase by sodium cyanide. P/iarmaco/. Toxicol. 69 238-41. 

Ohm TG, Muller H, Ulfig N, Braak E. 1990. Glutamic-acid-decarboxylase- and parvalbumin-like-immunoreactive structures in the olfactory bulb of the human adult. J Comp Neurol 291 1-8. 

As mentioned, GABA is an important neural transmitter and deficiencies in GABA are associated with diseases that exhibit neuromuscular dysfunction such as epilepsy, Huntington s disease and Parkinson s disease. S-Aminopentanoic acid (S-aminovaleric acid, DAVA) is also a neurotransmitter and used for treatment of neuromuscular disease. In at least one study, 3-alkyl-4-aminobutanoic acid derivatives were shown to be in vitro activators of f glutamic acid decarboxylase and they showed anti-convulsant activity. ... 

D.T. /helan, C.R. Scriver and F. Mohyuddin. Glutamic acid decarboxylase and Jf-aminobutyric acid in mammalian kidney. Nature, 1969, 224 916. 

The configuration of the amino acids was determined by using l-glutamic acid decarboxylase and D-amino acid oxidase. The complete structure of viscosin was thus established as (50) (720). 

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