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Glucuronidation/glucuronosylation

Polyphenols and flavanoids in rat liver microsomal fractions have been demonstrated to inhibit glucuronidation of estrone and estradiol in vitro (Zhu et al, 1998). In addition, flavonoids have also been found to induce phase I and II enzymes in rats including UDP-glucuronosyl transferase (Seiss et al, 1996). However, the effects of phytoestrogens have not been evaluated for either their inhibition or induction of glucuronosyl transferase activity. [Pg.68]

Glucuronosyl(l 2)glucuronide Perilla ocimoides leaves Labiatae 61... [Pg.753]

Feruloylglucuronosyl) (1 2)glucuronide 7-[Glucuronosyl(l 3)(2" -feruloylglucuronosyl)] (1 2)glucuronide Luteolin 4 -methyl ether (diosmetin)... [Pg.756]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

Acyl glucuronide Diclofenac Glucuronosyl transferase Hepatic toxicity... [Pg.119]

Figure 7.16 Reaction sequences of uridine diphospho glucuronosyl transferase and chemical structures of compounds that form glucuronides. Arrows indicate the position on each molecule where glucuronidation occurs. Figure 7.16 Reaction sequences of uridine diphospho glucuronosyl transferase and chemical structures of compounds that form glucuronides. Arrows indicate the position on each molecule where glucuronidation occurs.
Glucuronidation UDP glucuronic acid UDP glucuronosyl- transferase (microsomes) Phenols, alcohols, carboxylic acids, hydroxylamines, sulfonamides Nitrophenol, morphine, acetaminophen, diazepam, N-hydroxydapsone, sulfathi azole, meprobamate, digitoxin, digoxin... [Pg.80]

Burchell B, Brierley CH, Ranee D. Specificity of human UDP-glucuronosyl-transferases and xenobiotic glucuronidation. Life Sci 1995 57(20) 1819—1831. [Pg.113]

Mutlib AE, Goosen TC, Bauman JN, et al. Kinetics of acetaminophen glucuronidation by UDP-glucuronosyl transferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced toxicity. Chem Res Toxicol 2006 19 701-709. [Pg.706]

Glucuronidation of many substrates is low or undetectable in fetal mammalian tissues but increases with age. The rate of development is dependent upon the species, tissue, and substrate. The inability of newborns of most mammals, except the rat, to form glucuronides is associated with deficiencies in glucuronosyl transferase activity and the cofactor, UDPGA. The blood serum of newborn babies may contain pregnandiol, which is an inhibitor of glucuronide formation. Suppressed glucuroniation of bilirubin in newborns can result in neonatal jaundice. [Pg.223]

A number of arylamines are potent bladder carcinogens such as 4-aminobiphenyl, 1-naphthylamine, and benzidine. Metabolic activation of these carcinogens requires the action of UDP-glucuronosyl transferase on N-hydroxyarylamines to form N-glucuronides. [Pg.235]

The quantitatively most significant second-phase reaction of hepatic biotransformation is glucuronidation that takes place in the ER. The transfer of glucuronosyl group from... [Pg.398]

See other pages where Glucuronidation/glucuronosylation is mentioned: [Pg.167]    [Pg.179]    [Pg.130]    [Pg.202]    [Pg.251]    [Pg.37]    [Pg.481]    [Pg.753]    [Pg.758]    [Pg.810]    [Pg.811]    [Pg.811]    [Pg.812]    [Pg.813]    [Pg.816]    [Pg.816]    [Pg.818]    [Pg.823]    [Pg.142]    [Pg.163]    [Pg.304]    [Pg.1404]    [Pg.270]    [Pg.138]    [Pg.183]    [Pg.87]    [Pg.697]    [Pg.155]    [Pg.734]    [Pg.221]    [Pg.221]    [Pg.319]    [Pg.120]    [Pg.396]    [Pg.1926]   


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Glucuronidated

Glucuronidation

Glucuronides

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