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Glucuronic Acid and Sulfate Conjugates of Target Analytes

11 GLUCURONIC ACID AND SULFATE CONJUGATES OF TARGET ANALYTES [Pg.212]

One of the major advantages of LC-ESI-MS(/MS) over GC-MS is the capability to analyze intact glucuronic add or sulfate conjugates of target compounds and/or their phase-I-metabolites. This is particularly useful, e.g., when sample preparation steps required to hydrolyze phase-H-metabolites are difficult to verify, when intact phase-II-metabolites are to determine, or when more than one conjugation site is present in a phase-I-metabolite and the position of the glucuronic add or sulfate moiety is to be located. [Pg.212]

There are several examples of analytes relevant for doping controls that were studied in terms of their phase-II-metabolism using ESI-MS (/MS) such as anabolic steroids, 2.5.28,123 128 narcotics, stimulants, ° etc. These studies outlined the fact that the CID behavior of the con- [Pg.212]

Thevis, M., and Schanzer, W. (2007) Current role of LC-MS(/MS) in doping control. Analytical and Bioanalytical Chemistry, 388,1351-1358. [Pg.214]

and Henion, J.D. (1997) Direct determination of anabolic steroid conjugates in human urine by combined high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography B, 690,65-75. [Pg.214]




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Acidic analyte

Acidic analytes

Conjugate acid and

Conjugation of glucuronic acid

Glucuronate

Glucuronate/glucuronic acid

Glucuronates

Glucurone

Glucuronic

Glucuronic acid conjugates

Glucuronic acid conjugation

Sulfate conjugates

Sulfate conjugation

Sulfates acidity

Sulfation/sulfate conjugate

Target analyte

Target analytes

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