Glucose regulation

Clinical features NCEPATPIII criteria S3 of the criteria below WHO criteria impaired glucose regulation/insulin resistance and >2 other criteria... 

As more is learned about the chromosomal effects on HS gene expression, it is important to point out that these genes are actually a subset of inducible responses to cellular stress. Not all of these inducible responses involve HSF, and this indicates that cells have diversified transcriptional responses to cope with different types of stress. This diversification is manifested by glucose regulated genes (grp), as well as the metallothionein and oxidant-injury genes (Watswich, 1988 Storz et al., 1990 Devary et al., 1992 Skroch et al., 1993 Xu, 1993). 

Pelham, H.R.B. (1986). Speculations on the functions of the mayor heat shock and glucose regulated proteins. Cell 46,959-961. 

Ferromagnetic 0.213 Blood glucose regulators after intra-articular injection Insulin, triamcinolone diacetate... 

Messier C, Desrochers A and Gagnon M (1999). Effect of glucose, glucose regulation, and word imagery value on human memory. Behavioral Neuroscience, 113, 431 -38. 

Webb GC et al. Expression profiling of pancreatic (S cells glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci USA 2000 97 5773-5778. 

Normal glucose regulation WHO (1999) FPG <6.1 mmol/1 and 2-h post glucose load <7.8 mmol/1... 

Figure 7.2 Glucose regulation by insulin. Increased concentrations of glucose and amino acids in the circulation, vagus nerve stimulation and circulating hormones e.g. GLP) stimulate insulin secretion by 3-cells of the pancreatic islets. Insulin suppresses glucose production by the liver and increases glucose uptake by skeletal muscle and fat, leading to decreased circulating glucose concentrations.

This is an antihyperglycemic drug for non-insulin dependent diabetes. It is a blood glucose regulator. It lowers the amount of glucose produced by the liver, reduces the amount of glucose absorbed from food, and helps cells use glucose. Metformin increased 21% in prescriptions for one year. 

Munro, S and Pelham, H. R. B (1986) An HSP70-like protein in the ER identity with the 78kD glucose-regulated protein and immunoglobulin heavy chain binding protein Cell 46,291-300. 

Damsbo P, Marbury TC, Hatorp V, Clauson P, Muller PG. Flexible prandial glucose regulation with repaglinide in patients with type 2 diabetes. Diabetes Res Clin Pract 1999 45(1) 31—9. 

Kalbag JB, Walter YH, Nedelman JR, McLeod JF. Mealtime glucose regulation with nateglinide in healthy volunteers comparison with repaglinide and placebo. 

Zhou H, Walter YH, Smith H, Devineni D, McLeod JF. Nateglinide, a new mealtime glucose regulator. Lack of pharmacokinetic interaction with digoxin in healthy volunteers. Clin Drug Invest 2000 19 465-71. 

Hatorp V, Hansen KT, Thomsen MS. Influence of drugs interacting with CYP3 A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. J Clin Pharmacol 2003 43(6) 649-60. 

In 48 patients with schizophrenia taking clozapine, olanzapine, risperidone, or typical neuroleptic drugs, and 31 untreated healthy control subjects newer neuroleptic drugs, such as clozapine and olanzapine, compared with typical agents, were associated with adverse effects on blood glucose regulation (774). 

Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry 2002 59(4) 337 15. 

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