Prandial glucose regulators

Damsbo P, Marbury TC, Hatorp V, Clauson P, Muller PG. Flexible prandial glucose regulation with repaglinide in patients with type 2 diabetes. Diabetes Res Clin Pract 1999 45(1) 31—9. 

Hatorp V, Hansen KT, Thomsen MS. Influence of drugs interacting with CYP3 A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. J Clin Pharmacol 2003 43(6) 649-60. 

Prandial glucose regulators are relatively new oral hypoglycaemics. Examples are nateg-linide and repaglinide. They stimulate insulin release from P-cells in the pancreas. They are conveniently taken just before each main meal and have a rapid onset and short duration of action. They should be used together with metformin if glucose control is not sufficient with metformin alone. 

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