Glucose-6-phosphate deficiency ascorbic acid

Also at risk of hemolysis are patients with glucose-6-phosphate dehydrogenase deficiency, in whom ascorbic acid can denature hemoglobin and reduce erythrocjde glutathione concentrations one such case proved fatal (18). This was further demonstrated by reports of hemolytic effects (19) in two young subjects with glucose-6-phosphate dehydrogenase deficiency hemolysis was induced by excessive intake of fizzy drinks fortified with ascorbic acid (20). 

Rees DC, Kelsey H, Richards JD. Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency. BMJ 1993 306(6881) 841-2. 

Glucuronate, once formed, can reenter the pathways of glucose metabolism through reactions that eventually convert it to D-xylulose 5-phosphate, an intermediate of the pentose phosphate pathway. In most mammals other than humans, an intermediate of this pathway is the precursor of ascorbic acid (vitamin C). Humans, however, are deficient in this pathway and cannot synthesize vitamin C. 

Effect of ascorbic acid on copper-induced oxidative changes in erythrocytes of individuals with a glucose-6-phosphate dehydrogenase deficiency. 

Effects of ascorbic acid on glucose-6-phosphate dehydrogenase-deficient erythrocytes studies in an aninial model. 

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