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Glucose 3-fluoro

Dihydropyridines 1,9-Pyrazoloanthrone (SP600125) 2-Acetylaminofluorene 2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) 2-Chloro-N6-(3-iodobenzyl)-adenosine-5 -N-methyluronamide 2-Deoxy-D-glucose 2-Fluoro N10-substituted acridones 2n-Propylquinoline 2-Phenyl-5-(pyrrolidin-l-yl)-... [Pg.489]

A mixture of methyl 3-deoxy-3-C-methyl-3-nitro-ct-D- and fi-L-glucopyranosides d l is formed by the reaction of nitroethane with the sugar thaldehyde obtained from L-glucose The products are separated and converted into branched-chain fluoro nitro l- and L-sugars fEq 361 ... [Pg.49]

Deoxy-2-[18F]fluoro-D-glucose (labelled) or (2fl)-2-deoxy-2-[18F]fluoro-D-arab/no-hexose... [Pg.91]

Syntheses of 3-deoxy-3-fluoro sugars are described next. A rapid synthesis aimed at 3-deoxy-3-[ F]fluoro-D-glucose ( F-3DFG) was developed. ... [Pg.133]

Deoxy-5-fluoro-D-glucose and -L-idose were synthesized from 1,2-(9-isopropylidene-a-D-glucofuranurono-6,3-lactone (285). Treatment of l,2-0-isopropylidene-5-0-triflyl-a-D-gluco- (286 prepared from 285) and -) -L-ido-furanurono-6,3-lactones (289 prepared from 288), with BU4NF... [Pg.137]

Deoxy-3-fluoro-D-glucose (25%) and -mannose (40%) were prepared from 2-deoxy-2-fluoro-D-arabinose by a chain-extension reaction (cyanohydrin synthesis). Likewise, 4-deoxy-4-fluoro-D-glucose ° (27%) and -mannose (45%) were prepared from 3-deoxy-3-fluoro-D-arabinose. ... [Pg.183]

Coe and Bessell and coworkers studied the metabolic fates of 2-deoxy-2-fluoro-D-glucose (2DFG) and related compounds by using yeast hexokinase (as a model for mammalian hexokinase), and determined the kinetic constants K and V ) of the Michaelis-Menten equation D-glucose 0.17 (K in mAf)> 1 00 (relative value, D-glucose taken as 1) 2DG 0.59 0.11, 0.85 2DFG 0.19 0.03, 0.50 2-deoxy-2-fluoro-D-mannose (2DFM) 0.41 0.05, 0.85 2-deoxy-2,2-difluoro-D-nraZ>//Jo-hexose... [Pg.188]

Deoxy-3-[ F]fluoro-D-glucose ( F-3DFG) was prepared - 454,467,473-476 essentially according to the procedure for the cold synthesis (see Section 11,2), namely, treatment of248 with Cs F (in DMF or HMPA), tetraalkylammonium [ F]fluoride (DMF, HMPA, or MeCN) or K F (in acetamide). 6-Deoxy-6-[ F]fluoro-a-D-galactopyranose was likewise pre-pared aceording to the cold synthesis. ... [Pg.199]

The incorporation and metabolism of 2-deoxy-2-fluoro-D-[ H]glucose and -D-[ H]mannose in yeast and chick-embryo cells has been studied. 2-Deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose, and their GDP and UDP derivatives were found to interfere with protein (involving that of... [Pg.206]

Deoxy-3-fluoro-D-glucose (see Section 11,2), a weak substrate for yeast hexokinase, is phosphorylated enzymically - to give the 6-phosphate 588, which is transformed into 2-deoxy-2-fluoro-D-arabinose 5-phos-phate (589) by lead tetraacetate oxidation. [Pg.208]

A limited number of pure substances are available from NIST, primarily clini-cally-relevant compounds such as cholesterol, urea, uric acid, creatinine, glucose, cortisol, tripalmitin, and bilirubin (NIST SRM website). These compounds are certified for purity (greater than 99 %) and are used as primary calibrants in definitive methods for these clinical analytes (see below). Several additional pure substances are available for specific applications such as microchemistry, i.e. elemental composition (acetanilide, anisic acid, cystine nicotinic acid, o-bromobenzoic acid, p-fluoro-benzoic acid, m-chlorobenzoic acid), polarimetric standards (sucrose and dextrose), acidimetric standard (benzoic acid and boric acid). Only three pure substance NIST RMs are available for environmental contaminants, namely the chlorinated pesticides, lindane, 4,4 -DDT, and 4,4 -DDE. [Pg.85]

Volkow ND, Gillespie H, Mullani N, Tancredi L, Grant C, Ivanovic M, Hollister L. Cerebellar metabolic activation by delta-9-tetrahydrocannabi-nol in human brains. A study with positron emission tomography and 18F-2-deoxy-2-fluoro-D-glucose. Psychiat Res 1991 40 69-80. [Pg.150]

Formation of the oxazoline reduced undesirable 18F-19F exchange and the desired product was rapidly (15s) isolated in good yield (45-55%) with a specific activity (1.1 GBq pmol-1) that was 20 times higher than that obtained when using direct debromination route. In another example, the synthesis of 2-deoxy-2-18F-fluoro-D-glucose [110] the high purity of the product and the improved specific activity is attributed to the short reaction times that are made possible via the use of micro-... [Pg.458]

Phelps,M.E.,Huang,S.C.,Hoffman,E.J.eta/.Tomographic measurement of local cerebral glucose metabolic rate in humans with 18F 2-fluoro-2-deoxy-D-glucose validation of method. Ann. Neurol. 6 371-388,1979. [Pg.960]

See other pages where Glucose 3-fluoro is mentioned: [Pg.209]    [Pg.210]    [Pg.773]    [Pg.1014]    [Pg.1126]    [Pg.170]    [Pg.263]    [Pg.124]    [Pg.135]    [Pg.155]    [Pg.171]    [Pg.188]    [Pg.188]    [Pg.189]    [Pg.192]    [Pg.199]    [Pg.203]    [Pg.204]    [Pg.204]    [Pg.207]    [Pg.207]    [Pg.209]    [Pg.209]    [Pg.209]    [Pg.209]    [Pg.217]    [Pg.221]    [Pg.171]    [Pg.193]    [Pg.481]    [Pg.554]    [Pg.12]   
See also in sourсe #XX -- [ Pg.24 , Pg.48 , Pg.171 , Pg.175 , Pg.206 ]



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2- Deoxy-2-fluoro-D-glucose

Fluoro-deoxy-glucose

Glucose 6-phosphate, 2-deoxy-2- fluoro

Glucose 6-phosphate, 2-deoxy-2- fluoro synthesis

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