2-deoxy-2- fluoro-D-glucose

Coe and Bessell and coworkers studied the metabolic fates of 2-deoxy-2-fluoro-D-glucose (2DFG) and related compounds by using yeast hexokinase (as a model for mammalian hexokinase), and determined the kinetic constants K and V ) of the Michaelis-Menten equation D-glucose 0.17 (K in mAf)> 1 00 (relative value, D-glucose taken as 1) 2DG 0.59 0.11, 0.85 2DFG 0.19 0.03, 0.50 2-deoxy-2-fluoro-D-mannose (2DFM) 0.41 0.05, 0.85 2-deoxy-2,2-difluoro-D-nraZ>//Jo-hexose... 

The incorporation and metabolism of 2-deoxy-2-fluoro-D-[ H]glucose and -D-[ H]mannose in yeast and chick-embryo cells has been studied. 2-Deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose, and their GDP and UDP derivatives were found to interfere with protein (involving that of... 

Volkow ND, Gillespie H, Mullani N, Tancredi L, Grant C, Ivanovic M, Hollister L. Cerebellar metabolic activation by delta-9-tetrahydrocannabi-nol in human brains. A study with positron emission tomography and 18F-2-deoxy-2-fluoro-D-glucose. Psychiat Res 1991 40 69-80. 

Marinara R, Bray M, Gamin R, Doenst T, Goodwin GW, Taegtmeyer H. Fundamental limitations of [18F]2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation 1995 91 2435-2444... 

C. Y. Shiue, K.C. To, A.P. Wolf, A rapid synthesis of 2-deoxy-2-fluoro-D-glucose from xenon difluoride suitable for labelling with 18F, J. Label. Compds Radiopharm. 

C.R. Isasi, P. Lu, M.D. Blaufox, A metaanalysis of F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma, Cancer 104(5) (2005) 1066-1074. 

L.P. Adler, J.P. Crowe, N.K. al-Kaisi, J.L. Sunshine,, Evaluation of breast masses and axillary lymph nodes with [F-18] 2-deoxy-2-fluoro-D-glucose PET, Radiology 187 (3) (1993) 743-750. 

At concentrations of amphomycin that completely block the formation of Man-P-Dol, the incorporation ofa-linked D-mannose into lipid-linked oligosaccharides is not completely inhibited.347 As was mentioned in Sections II,2,a and II,2,b, EDTA in vitro and 2-deoxy-2-fluoro-D-glucose in vivo have a similar effect, namely, the formation of a heptasaceharide-lipid, Man5(GlcNAc)2-PP-Dol, is still possible in the absence of Man-P-Dol. The question as to whether these D-man-nosyl residues come directly from GDP-Man is discussed in Section II,2,b. 

T. J. Hewson, Procedures, pitfalls and solutions in the production of [,sF]2-deoxy-2-fluoro-D-glucose A paradigm in the routine synthesis of fluorine-18 radiopharmaceuticals, NucL Med. Biol. 16 533 (1989). 

A recent report of the synthesis of 2-deoxy-2-fluoro-D-glucose by direct fluorination at -78°C in CFC13 is quite interesting (97). 

J. Pacak, J. Podesva, Z. Tocik, and M. Cerny, Syntheses with anhydro sugars. 11. Preparation of 2-deoxy-2-fluoro-D-glucose and 2,4-dideoxy-2,4-difluoro-D-glucose, Collect. Czech. Chem. Commun., 37 (1972) 2589-2599. 

T. J. Tewson and M. Soderlind, I-Pwpenyl 4,6-0-benzylidene-p-D-mannopyranoside-2,3-cyclic sulfate A substrate for the synthesis of [F-18] 2-deoxy-2-fluoro-D-glucose, J. Carbo-hydr. 4 529 (1985). 

Ido, T., Wan, C. N., Casella, V., et al. (1978) Labeled 2-deoxy-D-glucose analogs. Fluorine-18-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose. J Labeled Com. Radiopharm. 14, 175-183. 

T. Haradahira, M. Maeda, Y. Kai, H. Oinae, andM. Kojima, Improved syndiesis of 2-deoxy-2-fluoro-D-glucose using fluoride iou, Ckem Pharm BuU. 33 165 (1985). 

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