The glucagon receptor

Other uptake-linked receptors found on the SECs are the Fc receptor for the uptake of immunoglobulins [19], the CD14 receptor for the binding of lipopolysaccharide (EPS) bound to EPS binding protein [20], the platelet derived growth factor AA receptor [21] and the glucagon receptor [22]. 

R. Iyengar (1986). Structural characterization of the glucagon receptor. In N. Kraus-Friedman (Ed.). Hormonal Control of Gluconeogenesis, vol. 2. Boca Raton CRC Press, pp. 21-34. 

The glucagon receptor is a member of the G-protein-coupled family of receptors. 

This is a protein labeling reagent which readily reacts with amines and other nucleophilic functional groups. This reagent has been used, for example, to study the glucagon receptor in hepatocyte plasma membranes lodosulfanilic acid... 

This stimulation occurs via an intermediary protein called G protein In general, all 7 transmembrane domain proteins, including the glucagon receptor, act directly on a protein called G protein. With activation, G protein can stimulate adenyly I cyclase, or one of a variety of other enzymes. The orientation of the three membrane-bound proteins, mentioned earlier, is shown in the following diagram ... 

Binding of glucagon to the glucagon receptor on the plasma membrane of liver cells results in an increase in cytoplasmic cyclic AMP content. A similar effect is evoked by binding of epinephrine to P-adrenoceptors on the liver plasma membrane. Cyclic AMP turns on the activity of glycogen phosphorylase in the bicyclic fashion as described above. The advantage of this bicyclic-regulatory system is that it provides a very effective amplification mechanism. In combination with the... 

Another method of analysis which may provide useful clues to the intermolecular forces involved in the glucagon-receptor complex is a comparison of the primary structures of glucagon and a very similar peptide hormone, secretin. The sequences of the two hormones are ... 

The glucagon receptor is a glycoprotein, but in contrast to what is observed with insulin, treatment with phospholipase inhibits hormone receptors binding rather than activating it. 

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