Single nephron glomerular filtration rate

The clinical use of cisplatin is limited by nephrotoxicity, characterized by a decline in glomerular filtration rate that is in proportion to the number of cycles of cisplatin chemotherapy. Progressive and persistent reductions in glomerular filtration rale and renal blood flow may follow each successive treatment cycle [17]. Renal plasma flow, whole kidney glomerular filtration rate, single nephron glomerular filtration rate, and stop-flow pressure are reduced compared to controls... 

Abbreviations renal blood flow (RBE), renal plasma flow (RPE), glomerular filtration rate (GFR), single nephron glomerular filtration rate (SNGFR), tubuloglomerular feedback (TGF). 

PPD paraphenylene diamine SNGFR single nephron glomerular filtration rate... 

NKF K/DOQI National Kidney Foundation Kidney Disease Outcomes Quality Initiative NMN Al-1-methylnicotinamide PAH p-aminohippurate Per creatinine production rate Pier plasma creatinine level P-gp P-glycoprotein RBF renal blood flow RPF renal plasma flow Ser serum creatinine concentration SNGFR single nephron glomerular filtration rate SUN serum urea nitrogen (concentration)... 

Loss of one kidney during life or being born with a single kidney may cause slight renal dysfunction but, in general, does not lead to CRF even in late adulthood (Wikstad et al. 1988). CRF can be defined as a disease state with the loss of more than 50% of nephrons, persistently increased serum creatinine above +2 SD of the age-adjusted mean, and a decreased glomerular filtration rate (GFR). It is important to note that serum creatinine must be adjusted for age as, for example, a value of 1.0 mg/dl (88 pmol/1) is normal for an adolescent, but means CRF for an infant. CRF implicates a relentless pro-... 

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