Global network dynamics

Buescher, J.M. et al (2012) Global network reorganization during dynamic adaptations of Bacillus suhtilis metabolism. Science, 335 (6072), 1099-1103. 

To understand the global mechanical and statistical properties of polymeric systems as well as studying the conformational relaxation of melts and amorphous systems, it is important to go beyond the atomistic level. One of the central questions of the physics of polymer melts and networks throughout the last 20 years or so dealt with the role of chain topology for melt dynamics and the elastic modulus of polymer networks. The fact that the different polymer strands cannot cut through each other in the... 

Cause-effect-relations of these dynamics in the value chain may still be obvious, when operating a simple value chain comprising few products, locations and production steps. Considering the global multi-stage, multilocation value chain network, price changes in raw materials cannot directly be related to intermediate or even sales products and their prices. This problem requires specific planning models and methods. 

Distribution planning covers transportation and inventory planning within the network, as well as the material balance calculation between sales, production and procurement. Global transportation planning considers the lead times between continents resulting in transit inventories differentiation of sent and received transportation quantities as shown in the requirements in section 4.1.5. Inventories are managed at the defined transfer point locations either with static or dynamic boundaries. 

Dynamic modeling and network simulation for globally distributed pharmaceutical manufacturing systems and other methods and tools... 

Sequences folding into the same structure form extended neutral networks that enable evolutionary dynamics to approach major peaks of fitness landscapes and eventually allow to reach the global optimum. 

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M. Global in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006 127 635-648. 

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