Glidants, characteristics

Controlled optimal particle size and size distribution ensures superior flow properties of coprocessed excipients and reduced reliance on addition of glidants. The volumetric flow properties of SMCC were studied in comparison with those of the physical mixture of its parent excipients (42). The particle size range of the two test samples was found to be similar, but the flow of coprocessed excipient was better than that of the physical mixture. A comparison of the flow properties of Cellactose with its parent excipients was also performed (5) by measuring the angle of repose and Hausner ratio, and Cellactose was found to have better flow characteristics than lactose or a physical mixture of cellulose and lactose. The spray-dried coprocessed product had a spherical shape and even surfaces, which resulted in improved flow properties. On similar terms, mechanically coating the 2% CSD over microfine cellulose powder resulted in improving its flow properties (43). 

Colloidal Silcion dioxide is an agent that has been commonly used as a glidant. Flow rate, density, as well as other related measurements, were conducted on four different excipients. The addition of 1% colloidal silicon dioxide increased the flow of the poorer flowing excipients but had lesser affects on the exipients that were of larger size and were better flowing. Increasing amounts of chlorpromazine hydrochloride markedly decreased the flow characteristics of all the various blends. The particle size of the excipient blend... 

S. Mangal, E Meiser, S. Lakio, D. Morton, I. Larson, The role of physico-chemical and bulk characteristics of co-spray dried 1-leucine and polyvinylpyrrolidone on glidant and binder properties in interactive mixtures. International Journal of Pharmaceutics, 479, 338-348, 2015. 

There are two major functional classifications of tablet excipients. The first class includes those additives which affect the compressional characteristics of the tablet, including diluents, binders and adhesives, lubricants, antiadherents, and glidants. The second class of excipients includes those which affect the biopharmaceutics, chemical and physical stability, and marketing considerations of the tablet. This category includes disintegrants, colors, flavors and sweeteners, and miscellaneous components such as buffers and adsorbents. All of these must meet certain criteria as follows ... 

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