Glibenclamide drug interactions

Antidiabetic drugs No expected interaction No expected interaction with chlorpropamide, insulin, phenformin, tolazamide, or tolbutamide No expected interaction with glibenclamide (in vitro study) No expected interaction... 

Fifteen type 2 diabetics stabilised taking glibenclamide 3.75 to 10 mg daily for at least 30 days had no changes in their 24-hour plasma glucose concentrations when eprosartan 200 mg twice daily was added, for a further 7 days. Concurrent use was safe and well tolerated and it was eoncluded that there is no clinically relevant interaction between these two drugs. ... 

Waiter-Sack IE, Bliesath H, Stotzer F, Huber R, Steinijans VW, Ding R, Mascher H, Wurst W. Lack of pharmacokinetic and pharmacocfynamic interaction between pantoprazole and glibenclamide in humans. Clin Drug Invest (199S ) 15, 253-60. 

Drugs that make the urine alkaline (e.g. sodium bicarbonate, carbonic anhydrase inhibitors) will reduce the elimination of memantine. Memantine should be used with caution with other NMDA antagonists, such as amantadine, ketamine and dextromethorphan, or concurrent use should be avoided, because of the theoretical increased risk of adverse effects. Memantine is predicted to interact with other drugs eliminated by the same renal secretion mechanism, but no important interaction was seen with glibenclamide, hydrochlorothiazide, metformin or triamterene. 

Islam SI, Masuda QN, Bolaji 00, Shaheen FM, Sheikh lA. Possible interaction between cyclosporine and glibenclamide in posttran lant diabetic patients. Ther Drug Mcnit( 996) 18, 624-6. 

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