Glial disease

Hematopoietic stem cell transplants as treatment for glial disease 513... 

Serrano A, Haddjeri N, Lacaille JC, RobitaUle R (2006) GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression. J Neurosci 26 5370-5382 Streit WJ, Conde JR, Harrison JK (2001) Chemokines and Alzheimer s disease. Neurobiol Aging 22 909-913... 

Figure 18.1 Typical tangle (T) and plaque (P) as visualised by silver impregnation in the cerebral cortex of a case of Alzheimer s disease. The extracellular plaque (10-50 pm diameter) consists of a central core of amyloid surrounded by glial processes and a number of neurites in a ring formation. The intracellular cytoplasmic tangle is composed of helical filaments in a paired format. (Reproduced with permission of Academic Press from Wischik and Crowther 1986)...

Hirsch EC. Glial cells and Parkinson s disease. J Neurol 2000 247 1158-1162. 

Moreover,bioactive lipids maybe considered dual messengers they modulate cell functions as messengers and they become part of the response of the nervous tissue to injury, broadly referred to as the inflammatory response. This response occurs in ischemia-reperfusion damage associated with stroke, various forms of neurotrauma, infectious diseases and neurodegenerative diseases such as Alzheimer s disease. Inflammation in the nervous system differs from that in other tissues. If the blood-brain barrier is broken, blood-borne inflammatory cells (e.g. polymorphonuclear leukocytes, monocytes, macrophages) invade the intercellular space and glial cells are activated, particularly microglia, which play a prominent role in the inflammatory response. These responses may... 

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