Gilham

Naylor and Gilham (1966) took another route they were able to link short DNA fragments to a complementary matrix without using an enzyme. The reactions were carried out in aqueous solution, and the molecules first had to be converted into a reactive state by chemical activation the activation agent used was a water-soluble carbodiimide. 

Even if the Naylor-Gilham experiment was successful, the question as to how the hexamers were formed still remains. 

Rosenberg, M., and Gilham, P.T. (1971) The isolation of 3 -terminal polynucleotides from RNA molecules. Biochim. Biophys. Acta 246, 337-340. 

Weith, H.L., Wiebers, J.L., and Gilham, P.T. (1970) Synthesis of cellulose derivatives containing the dihy-droxyboryl group and a study of their capacity to form specific complexes with sugars and nucleic acid components. Biochemistry 9, 4396-4401. 

MPTP N-demethyiation is cataiyzed by CYP2D6. in situ hybridization shows CYP2D6 localized in pigmented neurons of human substantia nigra (Gilham et al., 1997). 

Gilham DE, Cairns W, Paine MJ, Modi S, Poulsom R, et al. 1997. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization. Xenobiotica 27 111-125. 

Modi S, Gilham DE, Sutcliffe MJ, Fian FY, Primrose WU, et al. 1997. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a... 

Modi, S., Gilham, D. E., Sutcliffe, M. J., et al. (1997) l-Methyl-4-pheny 1-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6 allosteric effects of NADPH-cytochrome P450 reductase. Biochemistry 36, 4461-4470. 

The following brief summary is considered in more detail in the discussion of mechanism. Nitrogen 3 will normally be protonated as in uracil or unprotonated as in cytosine, serving as a hydrogen donor or acceptor, respectively. Substitution of any other function on this nitrogen atom invariably converts the normal base to a nonsubstrate component. This has been shown by Gilham (427) in the formation of a carbodiimide... 

Leong, A. S.-Y., and Gilham, P. 1989a. A rapid, microwave-stimulated method of staining melanocytic lesions. Stain Technol. <54 81-85. 

Hayes JA, Brunder MJ, Gilham PT, Gough GR (1985) Tetrahedron Lett., 26 2407... 

Oswald I, French C, Adam K, Gilham J (1982) Benzodiazepine hypnotics remain effective for 24 weeks. BMJ 284 860-863... 

LaBonte, E. D., Camarota, L. M., Rojas, J. C., Jandacek R. J., Gilham, D.E., et al. (2008) Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and... 

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