Gerhardt, Charles-Frederic

Gerhardt, Charles Frederic. 1844—1845. Precis de chimie organique. 2 vols. Paris Fortin, Masson ( Cie. 

In 1843, Charles Frederic Gerhardt (Strasbourg, 21 August 1816—19 August 1856) also prepared phenol by heating salicyhc acid with lime and gave it the name ph6nol . 

Another active principle soon extracted from plants was salicylic acid. Salicin, extracted from the willow tree, has been launched in 1876 by a Scottish physician, Thomas John McLogan It was in extensive competition with Cinchona bark and quinine and never became a very popular treatment for fever or rheumatic symptoms. The Italian chemist Raffaele Piria, after having isolated salicylalde-hyde (1839) in Spireae species, prepared salicylic acid from salicin in Dumas laboratory in the Sorbonne, Paris. This acid was easier to use and was an ideal step before future syntheses. Its structure was closely related to benzoic acid, an effective preservative useful as an intestinal antiseptic for instance in typhoid fever. Acetylsalicylic acid has been first synthesized by Charles Frederic Gerhardt in 1853 and then, in a purer form, by Johann Kraut (1869). Acetylsalicylic acid synthesis with carbolic acid and carbon dioxide was improved by Hermann Kolbe in1874, but in fact nobody noticed its pharmacological interest. 

Acetaminophen was first discovered in 1852 by the French chemist Charles Frederic Gerhardt, who also discovered aspirin a year later. His results were largely ignored, however, until a German chemist, Harmon Northrop Morse... 

Charles Frederic Gerhardt prepared acetylsalicylic add in 1853, though not in pure form (a) Gerhardt, C.F. (1853) Ann. Chem. Pharm., 87,149-79 ... 

S-45 French chemist Charles-Frederic Gerhardt formulates the idea of homologous series. 

What we now call aspirin, acetylsalicylic acid, was first synthesized in 1853 by Charles Frederic Gerhardt, but it was not until... 

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