Geodia cydonium

Muller, W. E., and Schacke, H. (1996). Characterization of the receptor protein-tyrosine kinase gene from the marine sponge Geodia cydonium. fVog. Mol Subcell Biol 17, 183-208. 

Gamulin, V. Skorokhod, A. Kavsan, V. Miiller, I.M. Miiller, W.E. Experimental indication in favor of the introns-late theory the receptor tyrosine kinase gene from the sponge Geodia cydonium. J. Mol. Evol., 44, 242-252 (1997)... 

Schacke, H. Rinkevich, B. Gamulin, V. Muller, I.M. Muller, W.E. Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge Geodia cydonium. J. Mol. Recog-nit., 7, 273-276 (1994)... 

Schroder HC, Badria FA, Ayyad SN, Batel R, Wiens M, Hassanein HMA, Kurelec B, Muller WEG (1998) Inhibitory effects of extracts liom the marine alga Caulerpa taxifolia and of toxin from Caulerpa racemosa on multixenobiotic resistance in the marine sponge Geodia cydonium. Environ Toxicol Pharmacol 5 119-126... 

Exposure of the marine sponge Geodia cydonium to nontoxic (non-apoptotic) concentrations of water pollutant tributyltin together with CLP (10 mcg/ml) led to apoptosis. Increased toxicity of tributyltin was at least partially attributed to inhibition of multixenobiotic resistance pump by CLP [60]. This important observation elucidates the potential effect of CLP in overcoming resistance against chemotherapeutic agents. 

Muller, W.E.G., A. Bernd, R.K. Zahn, B. Kurelec, K. Dawes, I. Muller, and G. Uhlenbruck Xenograft Rejection in Marine Sponges. Isolation and Purification of an Inhibitory Aggregation Factor from Geodia cydonium. Eur. J. Biochem. 116, 573 (1981). 

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