Genotype distribution

Jun G et al. Ethnic differences in poly CADP-ribose) polymerase pseudogene genotype distribution association with lung cancer risk. Carcinogenesis 1999 20 1465-1469. 

Pape, M., Posedi, J., Failing, K., Schnieder, T. and von Samson-Himmelstjerna, G. (2003) Analysis of the beta-tubulin codon 200 genotype distribution in a benzimidazole-susceptible and -resistant cythostome population. Parasitology 127, 53-59. 

Lesch et al. demonstrated that a functional 5-HTT promoter polymorphism is associated with the factor neuroticism in the revised NEO personality inventory (51). Specifically, individuals who carry the s/s (short promoter repeat) alleles of the 5-HTT, as compared with individuals with s/l (long) or 1/1 alleles, have increased neuroticism. Extension of these genetic studies to anxiety disorders by the same authors showed no differences in 5-HTT genotype-distribution between anxiety patients and comparison subjects, but among anxiety patients, carriers of the s/s alleles exhibited higher neuroticism scores (52). 

Table 1. Genotype distribution of offspring from intercrosses between PARG truce...

Within your class, how unique is your particular combination of A/u alleles By calculating an allele frequency, you can begin to answer this question. An allele frequency is the percentage of a particular allele within a population of alleles. It Is expressed as a decimal. You can calculate an allele frequency for the Alu PV92 insertion in your class by combining all your data. For example, imagine that there are 100 students in your class and the genotype distribution within the class is as follows ... 

In this part of the exercise, you will use chi-square analysis to determine whether or not there is any differecKe in the genotype distribution between your class and another population group. If the p-value that is calculated tor this (xxnparison is less than 0.05, then the different between your class and the other population group is probably real. If the p-value is greater than 0.05, then there is probably no difference between your class and the other population group. 

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