Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Genotoxicity aneuploidy

Ethyl alcohol is not a bacterial or mammalian cell mutagen in vitro Increased frequencies of sister chromatid exchanges and aneuploidies have been observed in the peripheral lymphocytes of alcoholics." Although some degree of genotoxicity may result from excessive alcohol drinking, it is not considered relevant to occupational exposures. ... [Pg.309]

Isopropyl acetate was negative in most genotoxic test systems hut was a weak inducer of aneuploidy. ... [Pg.413]

MEK was not mutagenic in Ames Salmonella) and Escherichia coli tests, but induced aneuploidy in Saccharomyces cerevisiae. MEK was not found to be genotoxic in the mouse lymphoma assay, in Chinese hamster ovary cell, unscheduled DNA synthesis assay, and micronucleus assays. [Pg.1662]

Direct genotoxic and mitogenic effects of asbestos, as well as of some manmade fiber s, have been detected in in vitro assays [e.g., (Dopp et al. 1997 Osgood 1994 Wang et al. 1999)]. The physical presence of phagocytosized fibers can interfere with chromosome segregation during mitosis and result in aneuploidy and... [Pg.535]

In principle, justification for including tests complementary to the Ames test is based on knowledge that genotoxic agents cause damage through various mechanisms that may not be detectable in the Ames test alone. For example, neither structural damage to chromosomes nor the induction of aneuploidy can be detected in the Ames test. As a result of such considerations, it follows that a battery of short-term in vitro tests is required to provide a... [Pg.38]

Dimethylarsinic acid (v) Mammalian cells genotoxic and clastogenic effects S S S S S dS0,4Si viability and growth of human 06118 Rats reduction in brain neuron viability apotopsis cancer promoter—bladder, kidney, liver, thyroid Mice carcinogenic, co-carcinogenic or cancer promoter—skin, bladder induction of aneuploidy ... [Pg.626]

While the potential mechanisms associated with formaldehyde-induced cancer are not completely understood, potential mechanisms of carcinogenicity include DNA reactivity (covalent binding), gene mutation, chromosomal breakage, aneuploidy and epigenic effects [14, 15 ]. Some new studies confirmed that genotoxicity may play a role in... [Pg.339]


See other pages where Genotoxicity aneuploidy is mentioned: [Pg.160]    [Pg.185]    [Pg.189]    [Pg.160]    [Pg.308]    [Pg.204]    [Pg.23]    [Pg.123]    [Pg.23]    [Pg.395]    [Pg.112]    [Pg.2684]    [Pg.226]    [Pg.261]    [Pg.264]    [Pg.292]    [Pg.309]    [Pg.38]    [Pg.189]    [Pg.1624]    [Pg.247]    [Pg.977]    [Pg.915]    [Pg.171]    [Pg.130]    [Pg.352]    [Pg.662]    [Pg.297]    [Pg.445]   
See also in sourсe #XX -- [ Pg.155 ]




SEARCH



Aneuploidy

GENOTOXIC

© 2024 chempedia.info