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Selective genomic effects

Kumar, R., D. S. Conklin, and V. Mittal. 2003. High-throughput selection of effective RNAi probes for gene silencing. Genome Res 13 2333-40. [Pg.260]

DNA construct will often contain an effect gene and a selectable marker gene (such as antibiotic or herbicide resistance), both of which are bracketed by promoter and terminator sequences. A plasmid vector carries this cassette of genetic information into the plant genome by one of the above methods. [Pg.655]

Notes Analysis (Joost and Methner, Genome Biol., 3(11) research 0063.1-0063.16,2002. http //genomebiology.com/ 2002/3/11 /research/0063). Profiling is performed in two phases. The first phase consists of a panel of 25 GPCR representing the families most commonly associated with off-target effects. Once a compound shows activity in one of the assays from the first set, full dose response is run on receptors within the same target family to assess selectivity (Phase 2). [Pg.121]

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Selectivity effects

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