Genome Sequencing Center

Washington University Genome Sequencing Center (http //genome.wustl.edu)... 

The Genome Sequencing Center focuses on the large-scale generation and analysis of DNA sequences. They have played an important role in the Human Genome Project. They also sequenced the genome of other species such as the chicken, C. elegans, planarian, chimpanzee, and drosophila. 

The following approach has been adopted at the Human Genome Sequencing Center of Washington University, St. Louis, and has proven successful in sequencing through stop regions of M13 or pUC subclones, and PCR products. 

GeneBank (Benson et al, 2002), the DNA database from the National Center for Biotechnology Information (NCBI), incorporates sequences from publicly available sources, primarily from direct author submissions and genome sequence... 

Influenza virus Influenza Research University of Texas Southwestern Medical Center Database Comprehensive, integrated data about influenza virus genome sequences, virus phenotypic characteristics, and results from surveillance activities for the discovery and development of influenza virus vaccines, diagnostics, and therapeutics (http //www.fludb.org/brc/home. do decorator=influenza)... 

While modem molecular genetics has been at the center of the biomedical revolution in research for about 25 years now, its latest development, genomics, has only just started to influence medical research. It is therefore appropriate to briefly describe the potential of studying whole genome sequences as a new tool in biomedical research. 

The National Center for Biotechnology Information (NCBI). Located at the National Library of Medicine in Bethesda, MD, USA. The home of the GenBank DNA sequence database PubMed literature search engine sequence search tools (e.g., PSI-BLAST) genomic sequence navigation tools. A substantial repository of resources in all areas of bioinformatics. 

Microbial genomes are sequenced by organizations worldwide, follow an annotation process (gene prediction and functional characterization) that is often specific to each sequencing center, and end up in one of the public sequence data repositories, such as GenBank in the United States, EMBL in Europe, and DDBJ in Japan. 

---