Genome project databases

McArthur AG et al. (2000) The Giardia genome project database. FEMS Microbiol Lett 189 271-273... 

McArthur AG, Morrison HG, Nixon JE, Passamaneck NQ, Kim U, Hinkle G, Crocker MK, Holder ME, Farr R, Reich Cl, Olsen GE, Aley SB, Adam RD, Gillin FD, Sogin ML (2000) The Giardia genome project database. FEMS Microbiol Lett 189 271-273 Meza I (1992) Entamoeba histolytica phylogenetic considerations. A review. Arch Med Res... 

Human Genic Bi-allelic Sequences Database Human Genome Project... 

For some model organisms, cDNA resources are already prepared and shared in the research community. Thus, when there is a need to study about functional genomics of a model organism, a search for appropriate cDNA resources open to the public should be made first. These lines of information may be found in genomic databases and/or Web sites of publicly funded genome projects. For example, human and mouse ORF clones are available from the ORFeome collaboration (http //www.orfeomecollaboration.org/html/index.shtml). 

Considering the apparent functional and structural (immunological crossreactivity) conservation between plant and vertebrate NPs, it should be possible to identify Arabidopsis sequences related to preproANP in databases upon completion of the Arabidopsis genome project which is expected within the current year. While still unpublished, such a sequence may have already been identified [5]. The molecular characterization of the cDNA-encoded polypeptide will eliminate all doubts as to whether or not NPs rank among plant peptide hormones. 

Because much of the homology modeling process can be automated, it is possible to develop databases of homology models automatically as genome projects produce new protein sequences. The user of such databases should be aware that automatically generated homology models can often be improved by user intervention in the modeling process (see Section D). 

Some mouse strains may develop a metabolic syndromelike phenotype or have pathologically high reward-related phenotype (see Mouse Phenome Project or Mouse Genome Informatix database for these phenotypes of interest e.g., metabolic syndrome-like phenotypes in NeilltmlRsld/NeilltmlRsld mice). Thus, their sucrose consumption may be abnormally affected and alternative methods of depression testing or other mouse strains may be required. 

FlyBase (1999) The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Research 27, 85-88. 

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