Genetics of Common Diseases

Several key principles should emerge from this review of the genetics of common diseases ... 

Manolio TA, Brooks LD, Collins FS (2008) A HapMap harvest of insights into the genetics of common disease. J Clin Invest 118 1590-1605... 

Kruglyak L. Prospects for whole genome linkage disequilibrium mapping of common disease genes. Nature Genet 1999 22 139-144. 

Kruglyak, L., "Prospects for Whole-Genome Linkage Disequilibrium Mapping of Common Disease Genes," Nat. Genet., 22,139-144 (1999). 

Previous discussion has dealt with diseases caused by an alteration in a single gene or in a specific chromosome. Most common diseases heart disease, cancer, diabetes, etc.) have substantial genetic components, but their causation is complex. This chapter reviews some basic principles of the genetics of common, complex diseases. 

The Genetic Analysis of Common Diseases Applications to Predictive Factors in Coronary Heart Disease, Sing, C. and Skolnick, M. (eds), Alan Liss, in press. 

Eaves, I. A., et al., The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes [see comments]. Nat Genet, 2000. 25(3) p. 320-3. 

Smith DJ, Lusis AJ 2002 The allelic structure of common disease. Hum Mol Genet 11 ... 

SNP-based genome-wide studies have not only been suggested as methods to identify the genetic underpinning of common diseases, but they may also allow for the elucidation of individual responses to drug treatment, which represents another important piece of the puzzle towards individualized medicine. 

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