Genetic predispositions, analysis

Several different expressions of risk may be quoted in an analysis, e.g., a risk averaged ov a whole population, an age-spedfic risk, or a risk for a particularly susceptible individual or subgroup. Such an individual or subgroup might be more susceptible because of genetic predisposition, exposine to another risk factor, e.g., cigarette smoke, or other reasons. 

Mallon E, Newson R and Bunker CB (1999) HLA-Cw6 and the genetic predisposition to psoriasis a meta-analysis of published serologic studies. Journal of Investigative Dermatology 113 693-695. 

ECD electron capture detector Ecogenetics genetic predisposition for an individual reaction to environmental factors edema pathological accumulation of fluid in the tissue spaces (also known as dropsy) EDS energy dispersive spectrometry EDTA ethyl enediamine tetraacetic acid (chelating agent) used in analysis and therapy... 

The recent data with CBZ-induced idiosyncratic toxicity illustrate the complexity of genetic predisposition - the genetic factors seem to vary with the clinical phenotype and ethnicity. Unlike abacavir, a formal cost-effective analysis for preprescription genotyping for CBZ-induced SJS has not been performed, and data on the uptake of testing are lacking. 

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