General Concentrate Management Costs

Senn SJ (1997) Statisticians and pharmacokineticists what can they learn liom each other. In Aarons L, Balant LP, Danhof M, et al. (eds), COST B1 medicine. The population approach measuring and managing variability in response, concentration and dose. European Commission Directorate-General Science, Research and Development, Geneva, pp. 139-146. 

We will not dwell further on the subject of work description, but rather concentrate on the factors of lateness and error. These are in practice quite closely linked working under pressure of time results in increased error. Obviously, one way to minimize potential claims from this source is to delay construction work until engineering work is complete and all materials and equipment are available. This generally is not an acceptable alternative, because of both the extra cost of financing an extended project, and delays in product availability. On the contrary, it is standard practice to appoint a construction manager very early in the project, even at the outset. This person will want to get on with the job, and be almost guaranteed to create the maximum pressure to get contractors on site and commence construction work. 

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