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Drug resistance gene transfer

Transduction involves the introduction of new genetic information via a bacteriophage (a virus that infects bacteria). In this situation the bacteriophage contains DNA, which can carry a gene for drug resistance. Transductive transfer of phage DNA is particularly important for the development of resistance among strains of S. aureus that become endowed with the ability to synthesize penicillinase. [Pg.172]

Lang, T.T., Seiner, M., Young, J.D., and Cass, C.E. (2001) Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells. Molecular Pharmacology, 60 (5), 1143-1152. [Pg.76]

Rafferty JA, Hickson I, Chinnasamy N, Lashford LS, Margison GP, Dexter TM, Fairbairn LJ. Chemoprotection of normal tissnes by transfer of drug resistance genes. Cancer Metastasis Rev 1996 15 365-383. [Pg.354]


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See also in sourсe #XX -- [ Pg.133 ]




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Drug resistance

Drug resistance gene

Drug-resistant

Gene transfer

Resistance transferable

Transfer resistance

Transferring genes

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