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Gene therapy vectors, tissue-specific adenovirus

The second delivery method, called in mvo, means that the virus is used to directly infect the patient s tissues. The most common vector for this delivery is the adenoviras (which is a DNA virus). A particular vector can be chosen based on specific receptors on the target tissue. Adenovirus has receptors in lung and liver cells, and it has been used in clinical trials for gene therapy of cystic fibrosis and ornithine transcarbamoylase deficiency. [Pg.412]

Doronin K, Kuppuswamy M, Toth K, Tollefson AE, Krajcsi P, Krougliak V, Wold WS. Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy. J Virol 2001 75(7) 3314-3324. [Pg.167]

See other pages where Gene therapy vectors, tissue-specific adenovirus is mentioned: [Pg.231]    [Pg.266]    [Pg.426]    [Pg.261]    [Pg.983]    [Pg.1129]    [Pg.160]    [Pg.358]   
See also in sourсe #XX -- [ Pg.185 , Pg.187 ]



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Gene therapy

Gene therapy adenoviruses

Gene therapy vectors

Specific Therapy

Tissue specificity

Tissue therapy

Tissue-specific

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