Gene host responses

Schmidt, A.M. and Stern, D.M. (2001) Receptor for AGE (RAGE) is a gene within the major histocompatibility class III region implications for host response mechanisms in homeostasis and chronic disease. Front. Biosci. 6, D1151-D1160. 

Lipids A first induce the expression of early inflammatory genes such as tumor necrosis factor- (TNF)-a, EL-1(3, type 2 TNF receptor, IP-10, D3, D8 and D2 genes [34]. Then further genes are activated such as other cytokines and receptors, adhesion molecules, acute-phase proteins, tissue factors, as well as the inducible NOS (NOS II). These cascades of events initiated by lipid A provoke in their target cells complex responses in vivo, whose relevance in the host response to tumor growth is reviewed below. 

Schall, T. J., Bacon, K., Toy, K. J., and Goeddel, D. V. (1990). Selective attraction of monoctyes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347, 669-671. Senkevich, T. G., Bugert, J. J., Sisler, J. R., Koonin, E. V., Darai, G., and Moss, B. (1996). Genome sequence of a human tumorigenic poxvirus Prediction of specific host response-evasion genes. Science 273, 813-816. 

Jaber Bl, Pereira JG, Bonventre JV, Balakrishnan VS. Polymorphism of host response genes implications in the pathogenesis and treatment of acute renal failure. Kid internal. 2005 67 14-33... 

LYP is considered by most observers to be a peculiar T-cell lymphoma that is contained within the skin by an effective immunologic host response. i Immu-nophenotypic analyses of LYP support this view because in most instances an aberrant phenotype that is comparable to that of ALCL is detected. CD4 positivity is common in both of those conditions. Clonal T-cell receptor gene rearrangements in LYP further solidify the conclusion that it is inherently a malignancybecause they are uncommon in benign reactive T-cell infiltrates. Eventually,... 

The host response to smallpox Analysis of the gene expression program in peripheral blood cells in a nonhuman primate model [pdf 897 kb] [248]... 

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