Gene Expression Studies of the Lungs with PET

PET Imaging to Detect the Time-Course of Transgene Expression in the Lungs 

In this same study (42), peak levels of gene expression were obtained 4 days after infection with the adenovector and increased by a factor of 2-3 over baseline measurements (Fig. 8.6). In contrast, in vitro assays of gene 

In any given study, the duration of transgene expression will be a function of several factors, including the species used, tissue transduced, and the extent to which an inflammatory response is invoked by the adenovector. For instance. 

PET Imaging to Evaluate Methods of Vector Delivery to the Lungs 

Although surfactant-based vehicles have been reported to allow more efficient adenovirus-mediated gene transfer and to facilitate vector dispersion in the lungs (62-65), the experimental evidence supporting this perception has not been especially strong. For instance, an increase in gene transfer efficiency may be obtained with surfactant-based vehicles when a low volume of delivery 

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