Gene delivery nanoscale

Nanoparticles are solid species of nanoscale size usually composed of an insoluble and biodegradable polymer or polymer blend (Figure 47. IB). Generally, the methods of preparation of such nanoparticles are simple and easy to scale-up. The drug is captured within the particle upon its preparation and is released upon degradation of the polymer in the body. The use of nanoparticles as carriers for drug and gene delivery has been... 

Cationic lipids and cationic polymers are designed as gene delivery systems on the nanoscale. Especially chitosan is under focus as a biodegradable, natural biopolymer, used both as the polyplex and also as a coating material for other polyplexes. Chitosan-coated poly(isohexyl cyanoacrylate) nanoparticles have also been developed for intravenous delivery of siRNA and no evidence of toxicity was observed after intravenous administration for 30... 

Kong, H.J., Hsiong, S., Mooney, D.J. Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Nano Letters 7,161-166 (2007)... 

Membrane bioreactors can be easily integrated with other systems, for example, with delivery of drugs or genes to individual cells achieved on the nanoscale using electroporation techniques. In one method developed in a recent patent, a flowthrough bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber was used [28]. 

Nanosilica can be used to deliver drugs, such as new genes, proteins, small-molecule drugs or other nanoscale materials. In particular, the versatility of either the silica surface or the pores could be utilized as an effective delivery vehicle. 

Y. Zheng, H. Chen, X. Zeng, Z. Liu, X. Xiao, Y. Zhu, D. Gu, L. Mei, Surface modification of TPGS-b-(PCL-ran-PGA) nanoparticles with polyethyleneimine as a co-delivery system of TRAIL and endostatin for cervical cancer gene therapy doi 10.1186/1556-276X-8-161, Nanoscale Res. Lett. 8 (2013) 1-12. 

---