GenBank redundancy

This is fundamental to the progress of genomics (and many other areas) of science. Generating data in a common exchangeable format, with a common lexicon of terms [47] in a single non-redundant location is a major goal. A number of examples exist, such as the DNA and protein sequence data in GenBank, EMBL or SwissProt [48-50]. 

SwissProt is, next to GenBank, the most important server for biologists, but it has a different philosophy behind it. In GenBank all entries are submitted by the authors themselves and underlie their authority in SwissProt all entries are screened by one person and his group, which makes entry acceptance slower (this speed has been increased by creating an accession buffer called trembl) but accuracy and efficacy is higher, and redundancy does not normally occur. 

International Nucleotide Sequence Database. URL http // www.ddbj.nig.ac.jp/. A joint compilation of heterogeneous sequence data into a redundant database. New and updated data shared daily by DNA Database of Japan (DDBJ). European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBD- Cambridge, U.K. URL http // www.ebi.ac.uk/Databases/. GenBank. NCBI. URL http // www.ncbi.nlm.nih.gov/Genbank/GenbankSearch.html. 

Non-redundant merge of SWISS-PROT, PIR, PRF, and proteins derived from GenBank coding sequences and PDB atomic coordinates Subset of nr which is new or modified within the last 30 days The SWISS-PROT database... 

These primer sequences are similar to ones used to clone human CRBP II (16) and were based on the rat CRBP II nucleotide and ammo acid sequences (17) and an N-terminal human CRBP II ammo acid sequence (iS). In the original primers (16), redundancy was incorporated at base 13 of primer 1 (A or G) and bases 13 and 22 of primer 2 (both C or T) The nonredundant primers described here are based on the sequence of hCRBP II cDNA clones obtained m that study (Genbank accession number U13831). 

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