GenBank

GenBank [32] is a text-numeric database of genetic sequences with more than 28 billion bases in 22 million sequences (January, 2003) from genetic research. The collection of all publidy available sequences is annotated with information such as sequence description, source organism, sequence length, or references. The database, estabhshed in 1967, is updated daily and produced by the National Center for Biotechnology Information (USA). 

The CA Registry of CAS also comprises 1.6 million protein and peptide sequences and over 21.6 milhon nudeic acid sequences from literature sources and from GenBank. 

GenBank National Center for Biotechnology Information, USA nucleic acid sequence biblio., sub- stance, se- quence 22 mio sequences 28 billion bases journals, author submis- sions STN online daily www.ncbi.nlm.- nih.gov... 

GenBank (NCBI, USA) EMBL Nucleotide Sequence Database (Europe) DDBJ (Japan) The three main nucleotide sequence databases, which are synchronised daiiy... 

GsnPept Compendium of amino acid translations derived from GenBank... 

GenBank National Institute of Health STN bio-sequences, DNA/RNA sequences... 

DA Benson, MS Boguski, DJ Lipman, J Ostell, BEE Ouellette. GenBank. Nucleic Acids Res 26 1-7, 1997. 

Biological raw data are stored in public databanks (such as Genbank or EMBL for primary DNA sequences). The data can be submitted and accessed via the World Wide Web. Protein sequence databanks like trEMBL provide the most likely translation of all coding sequences in the EMBL databank. Sequence data are prominent, but also other data are stored, e.g.yeast two-hybrid screens, expression arrays, systematic gene-knock-out experiments, and metabolic pathways. 

In the biosciences, a databank (or data bank) is a structured set of raw data, most notably DNA sequences from sequencing projects (e.g. the EMBL and GenBank databases). 

Species Strain Gene/ Protein No. of amino acids including N-terminal leader peptide/N-terminal leader peptide Lattice type GenBank accession no. 

GenBank identifier, gene name, ratio as a table... 

K. Recourt, J.M. Laats, T. Stolle-Smits, H.J. Wichers, C. van Dijk and C.E.M. Ebbelaar. GenBank Data Base (1995) Accession no. X85216. 

Fig. 1.3. (Opposite) COI genes of strongylid and other nematodes. Aligned COI sequences (from Sukhdeo etal., 1997 (where each is designated by the GenBank accession number), except for Ascaris suum ASCOI and C. elegans CECOI which are from Okimoto et al. (1992), O. volvulus COI which is from Keddie etal. (1998) and B. malayiCO sequence which is unpublished data of the author) were analysed using maximum parsimony and neighbour joining.

Fig. 6 Sequence alignment of the deduced amino acid sequence from the identified cDNA encoding PBAN and related peptides from Helicoverpa zea and Bombyx mori. The putatively expressed peptides are shown in boxes. The conserved amino acids are underlined in the B. mori sequence. Putative proteolytic posttranslational processing sites are shown in bold with glycine contributing the C-terminal amide. Sequences of PBAN-like peptides are also shown in Table 1. GenBank accession numbers H. zea - PI 1159 and B. mori - BAA05971...

Zhang T, Zhang L, Xu W, Shen J (2001) GenBank Direct Submission AAL05596... 

This is fundamental to the progress of genomics (and many other areas) of science. Generating data in a common exchangeable format, with a common lexicon of terms [47] in a single non-redundant location is a major goal. A number of examples exist, such as the DNA and protein sequence data in GenBank, EMBL or SwissProt [48-50]. 

Family Gem Gem symbol Tissues 9 Polarity2> Chromosome Ref. seq./ GenBank... 

The combination of GenBank cDNA sequence comparison and data from the public SNP database reveal the presence of several SNPs in MRP3, many of which involve non-synonymous amino acid changes (Table 9.3). These polymorphisms have not been functionally characterized and, therefore, the clinical pharmacological impact of such MRP3 variants remains unknown. 

Pizzagalli F, Hagenbuch B, Bottom-ley KM, Meier PJ. Identification of a new human organic anion transporting polypeptide OATP-F. GenBank Accession No AF260704 2001. 

Kim RB, Leake BF, Cvetkovic M. Molecular cloning of a human liver-specific transporter, NLT. GenBank Accession No AF097518 1998. 

---