Gelatin matrix

TEST-METHOD OF NITROXOLINE DETECTION AND DETERMINATION WITH THE REAGENTS IMMOBILIZED IN GELATIN MATRIX... 

Orion D (1995) Structure and function of the root-knot (Meloidogyne spp.) gelatinous matrix. Nematologica 41 395-397... 

Finally, control of fluorapatite particle size (from 15 nm to 200 pm) and morphology can be achieved by varying precipitation conditions using aqueous precipitation from a micro-emulsion or by biomimetic synthesis in a gelatin matrix [129],... 

In vitro release data of propranolol hydrochloride from the four formulations evaluated ovr a 24 h period are shown in Table 2. The decreasing rank order of drug release from these samples was observed to be as follows Methocel matrix> Avicel CL-611 matrix>PVA-gelatin matrix>emulsion base. The Methocel matrix, formulation A, exhibited the maximum release of the drug, whereas the drug released was at a minimum from the PVA-gelatin matrix, formulation... 

Fig. 1—Diffusion profile of propranolol hydrochloride as a function of square root of time (tl/2) from different polymeric matrices , Methocel matrix 0, Avicel CL-611 matrix , PVA-gelatin matrix o, emulsion base.

The second issue is the slow release in the body of the cross-linking aldehydic reagents used to cross-link and stabilize the gelatin microparticles. This will occur slowly in vivo as the gelatin matrix itself dissociates and goes into solution. However, the effect of low level, slow, localized, release of glutaraldehyde over a period of time has not been evaluated clinically and the issue remains open for discussion. 

Saegmueller B, Brehm G, Schneider S (2000) In situ generated photolytic silver in a gelatin matrix an approach for high-throughput SERS spectroscopy applying microtiter plates. Appl Spectrosc 54(12) 1849-1856... 

Storage, changes taking place in the gelatine matrix (reagent layer) will render the slides unusable. 

Microbial mats are communities in surface water ecosystems where bacteria and bacterial processes dominate. In microbial mats dissolved nutrients and metabolites are transformed by one-dimensional (vertical) molecular diffusion. The distinction between microbial mats and biofilms is not sharp. By definition (Fenchel et al, 1998), microbial mats are typically stratified vertically with respect to different functional types of bacteria. Microbial mats are thicker (often several millimeters) than biofilms. In microbial mats various types of filamentous prokaryotes are the most conspicuous part and they are responsible for the mechanical coherence of the mat. The mechanical stability of microbial mats is reinforced by the bacterial excretion of mucous polymers, producing a gelatinous matrix. 

An example of the first application is shown in Figure 2, which shows release of the highly water-insoluble hydrocortisone acetate from a gelatin matrix crosslinked with formaldehyde (J ). As indicated by the first-order dependence, drug is released by a simple diffusional process and the crosslinked gelatin simply provides cohesiveness for the drug particles. 

Figure 2. Release of hydrocortisone acetate from a cross-linked gelatin matrix. (Reprinted with permission from Ref. 1, Copyright 1980.)...

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