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Gavage lead administration

An adverse effect of lead on pregnancy rate has been noted in some animal studies (Kennedy et al. 1975). Acute-duration gavage administration of 390 mg lead/kg/day as lead acetate to rats resulted in a sharp decrease in pregnancy rates. This effect was not noted at 39 mg lead/kg/day. The study limitations include a lack of measurement of blood lead levels and lack of statistical analysis of pregnancy incidence. A decrease in the number of implantations was noted in untreated female mice that were mated to males that had been treated with 141 mg/kg/day lead chloride in the drinking water for 3 months... [Pg.198]

A low concentration (0.01% for BZC and 0.1% for PS) of these materials can lead to nasal lesions in the rat however, this level is known as safe for human nasal mucosa exposure Related to the composition of the diet along with stress of pregnancy, parturition, and lactation (not seen with same diet in males and nonpregnant females) daily gavage administration of lOmL/kg of corn oil is not recommended to pregnant rats Cause of toxicity is not clearly understood but, in part, may be related to an adaptive response due to excretion of osmotic agents at extremely high concentration parenteral use of a- and (t-CDs is not recommended... [Pg.438]

The possible role of the ethanol-inducible isozyme of cytochrome P-450 in the metabolism of carbon disulfide has been examined (Snyderwine et al. 1988). Rats were administered various alcohols (methanol, ethanol, isopropanol, and isobutanol) by gavage. Eighteen hours after alcohol administration, rats were administered carbon disulfide intraperitoneally at doses of 1, 100, or 625 mg/kg. The results showed that pretreatment of rats with these alcohols enhances the metabolism of carbon disulfide by increasing the ethanol-inducible isoform of cytochrome P-450 with isopropanol being most potent. Furthermore, the study authors indicate that alcohol induction of P-450-dependent carbon disulfide metabolism per se is not sufficient to result in carbon disulfide-induced hepatic damage although it does lead to the loss of specific cytochrome P-450 function. [Pg.106]


See other pages where Gavage lead administration is mentioned: [Pg.105]    [Pg.176]    [Pg.180]    [Pg.188]    [Pg.203]    [Pg.224]    [Pg.868]    [Pg.43]    [Pg.29]    [Pg.434]    [Pg.89]    [Pg.523]    [Pg.177]    [Pg.363]    [Pg.483]    [Pg.547]    [Pg.36]    [Pg.83]    [Pg.650]    [Pg.387]   
See also in sourсe #XX -- [ Pg.63 ]




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