Gastrointestinal transporter

Metallothionein in the gastrointestinal mucosa plays a role in the gastrointestinal transport of cadmium. Its presence in cells of the placenta impairs the transport of cadmium from maternal to fetal blood and across blood-brain barriers, but only when the concentration of cadmium is low. Newborns are virtually cadmium free, whereas zinc and copper are readily supplied to the fetus. Rapid renal concentration occurs mainly during the early years of life. 

D Fleisher. Gastrointestinal transport of peptides experimental systems. In MD Taylor, GL Amidon, eds. Peptide-Based Drug Design. Washington DC American Chemical Society, 1995, pp 500—523. 

Rehnberg GL, Hein JF, Carter SD, et al. 1985. Age-dependent changes in gastrointestinal transport and retention of particulate manganese oxide in the rat. J Toxicol Environ Health 16 887-899. 

Mihatsch WA, Hoegel J, Pohlandt F. Prebioitc oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants. Acta Paediatr 2006 95 843-848. 

Three active opioid reeeptors (p-, A-, and K-receptors) regulate a number of important physiologieal fimetions, such as pain, reward, mood, stress, gastrointestinal transport, and respiration by some neuronal pathways, and in the ease of A-reeeptor, also strong neurological functions. They... 

Volume 50 Gastrointestinal Transport Molecular Physiology Edited by Kim E. Barrett and Mark Donowitz... 

The absorption of sulfonylureas from the upper gastrointestinal tract is faidy rapid and complete. The agents are transported in the blood as protein-bound complexes. As they are released from protein-binding sites, the free (unbound) form becomes available for diffusion into tissues and to sites of action. Specific receptors are present on pancreatic islet P-ceU surfaces which bind sulfonylureas with high affinity. Binding of sulfonylureas to these receptors appears to be coupled to an ATP-sensitive channel to stimulate insulin secretion. These agents may also potentiate insulin-stimulated glucose transport in adipose tissue and skeletal muscle. 

Molecular target Gastrointestinal lipases Serotonin and noradrenaline transporter Cannabinoid-1 receptor... 

A new interpretation of salicylic acid transport across the lipid bilayer implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract. /. Pharmacol. 

Jackson. M. J., Drug transport across gastrointestinal epithelia, in Johnson, L. R. (ed.), Physiology of the Gastrointestinal Tract, 2nd ed., Raven Press, New York, 1987, pp. 1597-1621. 

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