Gastrointestinal tract immunoreactivity

Subsequent to the molecular cloning and cDNA sequence analysis of the delta opioid receptor, antireceptor antibodies were raised against synthetic peptides based on the deduced amino acid sequence of this receptor. To date, there have been a limited number of studies using antibodies directed toward the amino terminus of the cloned murine receptor to assess the distribution of delta opioid receptorlike immunoreactivity in the gastrointestinal tract, and these have been confined so far to the porcine small intestine. They have shown the presence of delta opioid receptor-immuno-reactive neurons and fibers in both the myenteric and submucosal plexuses and as well as in myenteric neurons maintained in primary culture [22, 23]. Receptor-like immunoreactivity in neuronal cell bodies appears to be localized in the cytoplasm and is likely to be trafficked to nerve terminals. These neurons are coimmunoreactive for the acetylcholine-synthesizing... 

Maitra A, Murakata LA, Albores-Saavedra J. Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid adenocarcinomas of the gastrointestinal tract. Am J Clin Pathol. 2001 115 689-694. 

Berson SA, Yalow RS. Nature of immunoreactive gastrin extracted from tissues of the gastrointestinal tract. Gastroenterology 60 215-222, 1971. 

The glandular portion of this UACL secretes immunoreactive EGF/urogastrone that is then available to combine with its receptors and to stimulate mucosal healing. It is likely that this process or variations of it represent a basic template whereby mucosal healing of the gastrointestinal tract mucosa occurs. 

Viale G, Doglioni G, Gambacorta M, et al. Progesterone receptor immunoreactivity in pancreatic endocrine tumors An immunocytochemical study of 156 NE tumors of the pancreas, gastrointestinal and respiratory tracts and skin. Cancer. 1992 70 2268-2277. 

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