Gastroesophageal reflux disease 11, receptor antagonists

GERD gastroesophageal reflux disease H2RA histamine2-receptor antagonist LES lower esophageal sphincter... 

Mosapride is a benzamide, structurally close to cisapride. This 5-HT4 receptor agonist, which is also a 5-HT3 and D antagonist, was launched for the treatment of gastroesophageal reflux disease (GERD) (Figure 8.71). 

Trade names Evoxin Motilium (Johnson Johnson) Indications Investigational antiemetic, gastroesophageal reflux disease (GERD), nausea and vomiting Category Dopamine receptor antagonist Half-life 7-8 hours... 

Nizatidine, a histamine-receptor antagonist (300 mg once daily at bedtime), is indicated in the management of duodenal ulcer, benign gastric ulcer, and gastroesophageal reflux disease (see also Table 10). 

Medical pain HI antihistamines appear to be effective in treating renal coUc pain, one of the most severe forms of pain. The mechanism involves the inhibition of renal vasodilatation in the occluded ureter, the inhibition of prostaglandin release, and prevention of spontaneous urethral contractions. H2 receptor antagonists are used for the treatment and maintenance of gastroesophageal reflux disease, peptic ulcer disease, and dyspepsia. 

Ranitidine Zantac Azantac Melfax Rantec Sostril Taural Histamine Hj-receptor antagonist mp 70 °C Soluble in water. Treatment of peptic ulcer, gastrointestinal bleeding, and gastroesophageal reflux disease. N02 H H... 

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