Gastric cancer curcumin

Several in vivo chemoprevention studies have been reported with curcumin in gastric cancers. In some of the chemoprevention studies, curcumin fed as dietary turmeric (2% or 5%) to mice and Syrian golden hamsters significantly inhibited the benzo[a]pyrene-induced forestomach tumors. Furthermore, the incidence and multiplicity of forestomach tumors induced by benzo[a]pyrene in female Swiss mice were significantly inhibited by pure curcumin given 2 weeks before, during and after the carcinogen treatment. Other studies also revealed the chemopreventive effect of curcumin on benzo[a]pyrene-induced... 

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Helicobacter pylori is a Group 1 oareinogen and is assoeiated with the development of gastric and colon cancer. Mahady et al. have demonstrated that eureumin inhibits the growth of H. pylori eagA+ mouse strains in vitro, and this may be one of the mechanisms by which curcumin exerts its ehemopreventive effeets. 

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